Structural delineation and computational design of SARS-CoV-2-neutralizing antibodies against Omicron subvariants

SARS-CoV-2 Omicron subvariants have evolved to evade receptor-binding site (RBS) antibodies that exist in diverse individuals as public antibody clones. We rationally selected RBS antibodies resilient to mutations in emerging Omicron subvariants. Y489 was identified as a site of virus vulnerability...

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Detalles Bibliográficos
Autores principales: Moriyama, Saya, Anraku, Yuki, Taminishi, Shunta, Adachi, Yu, Kuroda, Daisuke, Kita, Shunsuke, Higuchi, Yusuke, Kirita, Yuhei, Kotaki, Ryutaro, Tonouchi, Keisuke, Yumoto, Kohei, Suzuki, Tateki, Someya, Taiyou, Fukuhara, Hideo, Kuroda, Yudai, Yamamoto, Tsukasa, Onodera, Taishi, Fukushi, Shuetsu, Maeda, Ken, Nakamura-Uchiyama, Fukumi, Hashiguchi, Takao, Hoshino, Atsushi, Maenaka, Katsumi, Takahashi, Yoshimasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349087/
https://www.ncbi.nlm.nih.gov/pubmed/37452031
http://dx.doi.org/10.1038/s41467-023-39890-8

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