Lactate-dependent transcriptional regulation controls mammalian eye morphogenesis

Mammalian retinal metabolism favors aerobic glycolysis. However, the role of glycolytic metabolism in retinal morphogenesis remains unknown. We report that aerobic glycolysis is necessary for the early stages of retinal development. Taking advantage of an unbiased approach that combines the use of e...

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Detalles Bibliográficos
Autores principales: Takata, Nozomu, Miska, Jason M., Morgan, Marc A., Patel, Priyam, Billingham, Leah K., Joshi, Neha, Schipma, Matthew J., Dumar, Zachary J., Joshi, Nikita R., Misharin, Alexander V., Embry, Ryan B., Fiore, Luciano, Gao, Peng, Diebold, Lauren P., McElroy, Gregory S., Shilatifard, Ali, Chandel, Navdeep S., Oliver, Guillermo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349100/
https://www.ncbi.nlm.nih.gov/pubmed/37452018
http://dx.doi.org/10.1038/s41467-023-39672-2

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