Longitudinal in vivo metabolic labeling reveals tissue-specific mitochondrial proteome turnover rates and proteins selectively altered by parkin deficiency

Our study utilizes a longitudinal isotopic metabolic labeling approach in vivo in combination with organelle fraction proteomics to address the role of parkin in mitochondrial protein turnover in mice. The use of metabolic labeling provides a method to quantitatively determine the global changes in...

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Detalles Bibliográficos
Autores principales: Stauch, K. L., Totusek, S., Trease, A. J., Estrella, L. D., Emanuel, K., Fangmeier, A., Fox, H. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349111/
https://www.ncbi.nlm.nih.gov/pubmed/37452120
http://dx.doi.org/10.1038/s41598-023-38484-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349111/
https://www.ncbi.nlm.nih.gov/pubmed/37452120
http://dx.doi.org/10.1038/s41598-023-38484-0

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