Fracture healing in a mouse model of Hajdu–Cheney-Syndrome with high turnover osteopenia results in decreased biomechanical stability

Notch signaling regulates cell fate in multiple tissues including the skeleton. Hajdu–Cheney-Syndrome (HCS), caused by gain-of-function mutations in the Notch2 gene, is a rare inherited disease featuring early-onset osteoporosis and increased risk for fractures and non-union. As the impact of Notch2...

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Detalles Bibliográficos
Autores principales: Ballhause, Tobias Malte, Jiang, Shan, Xie, Weixin, Sevecke, Jan, Dowling, Christine, Dust, Tobias, Brandt, Sabine, Mertens, Peter R., Yorgan, Timur Alexander, Schinke, Thorsten, Frosch, Karl-Heinz, Baranowsky, Anke, Keller, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349118/
https://www.ncbi.nlm.nih.gov/pubmed/37452111
http://dx.doi.org/10.1038/s41598-023-38638-0

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