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Large Volume Paracentesis in Patients with Liver Cirrhosis Temporarily Diminishes Blood Cell Count

BACKGROUND: Large-volume paracentesis is the preferred treatment for patients with severe and refractory ascites. Several complications were reported during therapeutical paracentesis. However, there are very few published studies on the change in blood cell count after paracentesis. This study aime...

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Autores principales: Haghighat, Mahmood, Ataollahi, Maryam, Imanieh, Mohammad Hadi, Honar, Naser, Dehghani, Seyed Mohsen, Soheili, Marzieh, Mahdavi Mortazavi, Seyede Maryam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shiraz University of Medical Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349154/
https://www.ncbi.nlm.nih.gov/pubmed/37456206
http://dx.doi.org/10.30476/IJMS.2022.95859.2743
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author Haghighat, Mahmood
Ataollahi, Maryam
Imanieh, Mohammad Hadi
Honar, Naser
Dehghani, Seyed Mohsen
Soheili, Marzieh
Mahdavi Mortazavi, Seyede Maryam
author_facet Haghighat, Mahmood
Ataollahi, Maryam
Imanieh, Mohammad Hadi
Honar, Naser
Dehghani, Seyed Mohsen
Soheili, Marzieh
Mahdavi Mortazavi, Seyede Maryam
author_sort Haghighat, Mahmood
collection PubMed
description BACKGROUND: Large-volume paracentesis is the preferred treatment for patients with severe and refractory ascites. Several complications were reported during therapeutical paracentesis. However, there are very few published studies on the change in blood cell count after paracentesis. This study aimed to evaluate any changes in blood cell counts after ascites fluid drainage. METHODS: This study was conducted on patients with severe ascites and chronic liver disease who underwent large-volume paracentesis at Namazi Hospital, in Shiraz, Iran, between March 2021 and February 2022. A data gathering form containing the patient’s medical history, cause of cirrhosis, ascites fluid volume, as well as routine tests including primarily sodium, potassium, and basal creatinine, was filled out. Before and after the surgery, the total blood cell count was measured. Before the procedure, adjustment was made in the case of coagulopathy and albumin deficiency. The effect of factors such as the volume of drained fluid, splenomegaly, antibiotics, and steroid use was assessed on the changes in the number of blood cells. Using the JAMOVI 2.3.9 software, a paired t test and multiple regression were applied for statistical analysis (P<0.001). RESULTS: The study included 37 patients. After the paracentesis procedure, the number of blood cells significantly decreased in all groups (P<0.001). The followings are the amounts of each type of blood cells before and after the procedure: Platelet=153837±91862 and 115648±69136, red blood cells=3.53±0.784 and 3.22±0.705, white blood cells=12.3±7.78 and 8.6±5.5. None of the study variables, including drained volume, splenomegaly, antibiotics, and steroid use, were significant predictors of the changes in the blood cell count after paracentesis (P>0.001). CONCLUSION: The findings of the present study showed that children with tense ascites who had large-volume paracentesis might experience a sharp drop in blood cell count after the procedure, which was a transient physiological condition.
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spelling pubmed-103491542023-07-16 Large Volume Paracentesis in Patients with Liver Cirrhosis Temporarily Diminishes Blood Cell Count Haghighat, Mahmood Ataollahi, Maryam Imanieh, Mohammad Hadi Honar, Naser Dehghani, Seyed Mohsen Soheili, Marzieh Mahdavi Mortazavi, Seyede Maryam Iran J Med Sci Original Article BACKGROUND: Large-volume paracentesis is the preferred treatment for patients with severe and refractory ascites. Several complications were reported during therapeutical paracentesis. However, there are very few published studies on the change in blood cell count after paracentesis. This study aimed to evaluate any changes in blood cell counts after ascites fluid drainage. METHODS: This study was conducted on patients with severe ascites and chronic liver disease who underwent large-volume paracentesis at Namazi Hospital, in Shiraz, Iran, between March 2021 and February 2022. A data gathering form containing the patient’s medical history, cause of cirrhosis, ascites fluid volume, as well as routine tests including primarily sodium, potassium, and basal creatinine, was filled out. Before and after the surgery, the total blood cell count was measured. Before the procedure, adjustment was made in the case of coagulopathy and albumin deficiency. The effect of factors such as the volume of drained fluid, splenomegaly, antibiotics, and steroid use was assessed on the changes in the number of blood cells. Using the JAMOVI 2.3.9 software, a paired t test and multiple regression were applied for statistical analysis (P<0.001). RESULTS: The study included 37 patients. After the paracentesis procedure, the number of blood cells significantly decreased in all groups (P<0.001). The followings are the amounts of each type of blood cells before and after the procedure: Platelet=153837±91862 and 115648±69136, red blood cells=3.53±0.784 and 3.22±0.705, white blood cells=12.3±7.78 and 8.6±5.5. None of the study variables, including drained volume, splenomegaly, antibiotics, and steroid use, were significant predictors of the changes in the blood cell count after paracentesis (P>0.001). CONCLUSION: The findings of the present study showed that children with tense ascites who had large-volume paracentesis might experience a sharp drop in blood cell count after the procedure, which was a transient physiological condition. Shiraz University of Medical Sciences 2023-07 /pmc/articles/PMC10349154/ /pubmed/37456206 http://dx.doi.org/10.30476/IJMS.2022.95859.2743 Text en Copyright: © Iranian Journal of Medical Sciences https://creativecommons.org/licenses/by-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NoDerivatives 4.0 International License. This license allows reusers to copy and distribute the material in any medium or format in unadapted form only, and only so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Original Article
Haghighat, Mahmood
Ataollahi, Maryam
Imanieh, Mohammad Hadi
Honar, Naser
Dehghani, Seyed Mohsen
Soheili, Marzieh
Mahdavi Mortazavi, Seyede Maryam
Large Volume Paracentesis in Patients with Liver Cirrhosis Temporarily Diminishes Blood Cell Count
title Large Volume Paracentesis in Patients with Liver Cirrhosis Temporarily Diminishes Blood Cell Count
title_full Large Volume Paracentesis in Patients with Liver Cirrhosis Temporarily Diminishes Blood Cell Count
title_fullStr Large Volume Paracentesis in Patients with Liver Cirrhosis Temporarily Diminishes Blood Cell Count
title_full_unstemmed Large Volume Paracentesis in Patients with Liver Cirrhosis Temporarily Diminishes Blood Cell Count
title_short Large Volume Paracentesis in Patients with Liver Cirrhosis Temporarily Diminishes Blood Cell Count
title_sort large volume paracentesis in patients with liver cirrhosis temporarily diminishes blood cell count
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349154/
https://www.ncbi.nlm.nih.gov/pubmed/37456206
http://dx.doi.org/10.30476/IJMS.2022.95859.2743
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