QSP Designer: Quantitative systems pharmacology modeling with modular biological process map notation and multiple language code generation

Typical Quantitative Systems Pharmacology (QSP) workflows involve discussion of biology, supported by graphical diagrams, followed by construction of large Ordinary Differential Equation models. QSP Designer facilitates this process by providing enhanced graphical notation, which enables hierarchica...

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Detalles Bibliográficos
Autores principales: Matthews, Richard J., Hollinshead, David, Morrison, Daniel, van der Graaf, Piet H., Kierzek, Andrzej M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Tutorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349184/
https://www.ncbi.nlm.nih.gov/pubmed/37452454
http://dx.doi.org/10.1002/psp4.12972
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author Matthews, Richard J.
Hollinshead, David
Morrison, Daniel
van der Graaf, Piet H.
Kierzek, Andrzej M.
author_facet Matthews, Richard J.
Hollinshead, David
Morrison, Daniel
van der Graaf, Piet H.
Kierzek, Andrzej M.
author_sort Matthews, Richard J.
collection PubMed
description Typical Quantitative Systems Pharmacology (QSP) workflows involve discussion of biology, supported by graphical diagrams, followed by construction of large Ordinary Differential Equation models. QSP Designer facilitates this process by providing enhanced graphical notation, which enables hierarchical presentation with modules and handling of combinatorial complexity with diagram node arrays. Whereas the software includes a simulation engine, a major feature is full model code generation in MATLAB, R, C, and Julia to support multiple modeling communities.
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spelling pubmed-103491842023-07-16 QSP Designer: Quantitative systems pharmacology modeling with modular biological process map notation and multiple language code generation Matthews, Richard J. Hollinshead, David Morrison, Daniel van der Graaf, Piet H. Kierzek, Andrzej M. CPT Pharmacometrics Syst Pharmacol Tutorial Typical Quantitative Systems Pharmacology (QSP) workflows involve discussion of biology, supported by graphical diagrams, followed by construction of large Ordinary Differential Equation models. QSP Designer facilitates this process by providing enhanced graphical notation, which enables hierarchical presentation with modules and handling of combinatorial complexity with diagram node arrays. Whereas the software includes a simulation engine, a major feature is full model code generation in MATLAB, R, C, and Julia to support multiple modeling communities. John Wiley and Sons Inc. 2023-05-04 /pmc/articles/PMC10349184/ /pubmed/37452454 http://dx.doi.org/10.1002/psp4.12972 Text en © 2023 Certara. CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Tutorial
Matthews, Richard J.
Hollinshead, David
Morrison, Daniel
van der Graaf, Piet H.
Kierzek, Andrzej M.
QSP Designer: Quantitative systems pharmacology modeling with modular biological process map notation and multiple language code generation
title QSP Designer: Quantitative systems pharmacology modeling with modular biological process map notation and multiple language code generation
title_full QSP Designer: Quantitative systems pharmacology modeling with modular biological process map notation and multiple language code generation
title_fullStr QSP Designer: Quantitative systems pharmacology modeling with modular biological process map notation and multiple language code generation
title_full_unstemmed QSP Designer: Quantitative systems pharmacology modeling with modular biological process map notation and multiple language code generation
title_short QSP Designer: Quantitative systems pharmacology modeling with modular biological process map notation and multiple language code generation
title_sort qsp designer: quantitative systems pharmacology modeling with modular biological process map notation and multiple language code generation
topic Tutorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349184/
https://www.ncbi.nlm.nih.gov/pubmed/37452454
http://dx.doi.org/10.1002/psp4.12972
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