Cargando…

QSP Designer: Quantitative systems pharmacology modeling with modular biological process map notation and multiple language code generation

Typical Quantitative Systems Pharmacology (QSP) workflows involve discussion of biology, supported by graphical diagrams, followed by construction of large Ordinary Differential Equation models. QSP Designer facilitates this process by providing enhanced graphical notation, which enables hierarchica...

Descripción completa

Detalles Bibliográficos
Autores principales:	Matthews, Richard J., Hollinshead, David, Morrison, Daniel, van der Graaf, Piet H., Kierzek, Andrzej M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Tutorial
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349184/ https://www.ncbi.nlm.nih.gov/pubmed/37452454 http://dx.doi.org/10.1002/psp4.12972

Ejemplares similares

QSP‐IO: A Quantitative Systems Pharmacology Toolbox for Mechanistic Multiscale Modeling for Immuno‐Oncology Applications
por: Sové, Richard J., et al.
Publicado: (2020)

Using machine learning surrogate modeling for faster QSP VP cohort generation
por: Myers, Renée C., et al.
Publicado: (2023)

Frequency‐Domain Response Analysis for Quantitative Systems Pharmacology Models
por: Schulthess, Pascal, et al.
Publicado: (2017)

A model qualification method for mechanistic physiological QSP models to support model‐informed drug development
por: Friedrich, CM
Publicado: (2016)

Integration of Omics Data Sources to Inform Mechanistic Modeling of Immune‐Oncology Therapies: A Tutorial for Clinical Pharmacologists
por: Lazarou, Georgia, et al.
Publicado: (2020)

Logic Modeling in Quantitative Systems Pharmacology
por: Traynard, Pauline, et al.
Publicado: (2017)

Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery
por: Coussens, Nathan P., et al.
Publicado: (2018)

Introduction to dynamical systems analysis in quantitative systems pharmacology: basic concepts and applications
por: Chae, Dongwoo
Publicado: (2020)

A Six‐Stage Workflow for Robust Application of Systems Pharmacology
por: Gadkar, K, et al.
Publicado: (2016)

Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation
por: Ribba, B, et al.
Publicado: (2017)

Quantitative Systems Pharmacology and Physiologically‐Based Pharmacokinetic Modeling With mrgsolve: A Hands‐On Tutorial
por: Elmokadem, Ahmed, et al.
Publicado: (2019)

Building confidence in quantitative systems pharmacology models: An engineer's guide to exploring the rationale in model design and development
por: Timmis, J, et al.
Publicado: (2017)

Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics
por: Maldonado, Elaina M., et al.
Publicado: (2017)

Understanding the Behavior of Systems Pharmacology Models Using Mathematical Analysis of Differential Equations: Prolactin Modeling as a Case Study
por: Bakshi, S, et al.
Publicado: (2016)

The quest for balance between capturing data and model complexity: A quantitative clinical pharmacology approach applied to monoclonal antibodies
por: Pressly, Michelle A., et al.
Publicado: (2023)

Asia‐Inclusive Clinical Research and Development Enabled by Translational Science and Quantitative Clinical Pharmacology: Toward a Culture That Challenges the Status Quo
por: Venkatakrishnan, Karthik, et al.
Publicado: (2022)

MOCA: a systematic toolbox for designing and assessing modular functional near-infrared brain imaging probes
por: Vanegas, Morris, et al.
Publicado: (2022)

Tutorial: Speech Assessment for Multilingual Children Who Do Not Speak the Same Language(s) as the Speech-Language Pathologist
por: McLeod, Sharynne, et al.
Publicado: (2017)

Tutorial on High-Definition Map Generation for Automated Driving in Urban Environments
por: Jeong, Jinseop, et al.
Publicado: (2022)

Agent‐Based Modeling in Systems Pharmacology
por: Cosgrove, J, et al.
Publicado: (2015)

Quantitative systems pharmacology of the eye: Tools and data for ocular QSP
por: Kuepfer, Lars, et al.
Publicado: (2023)

PharmML in Action: an Interoperable Language for Modeling and Simulation
por: Bizzotto, R, et al.
Publicado: (2017)

Approaches to handling missing or “problematic” pharmacology data: Pharmacokinetics
por: Irby, Donald J., et al.
Publicado: (2021)

Biomarker‐Guided Individualization of Antibiotic Therapy
por: Aulin, Linda B.S., et al.
Publicado: (2021)

Effective Visual Communication for the Quantitative Scientist
por: Vandemeulebroecke, Marc, et al.
Publicado: (2019)

A quantitative systems pharmacology (QSP) model for Pneumocystis treatment in mice
por: Liu, Guan-Sheng, et al.
Publicado: (2018)

Sobol Sensitivity Analysis: A Tool to Guide the Development and Evaluation of Systems Pharmacology Models
por: Zhang, X‐Y, et al.
Publicado: (2015)

Speech-Language Disorders in 22q11.2 Deletion Syndrome: Best Practices for Diagnosis and Management
por: Solot, Cynthia B., et al.
Publicado: (2019)

MatVPC: A User-Friendly MATLAB-Based Tool for the Simulation and Evaluation of Systems Pharmacology Models
por: Biliouris, K, et al.
Publicado: (2015)

Applied Concepts in PBPK Modeling: How to Extend an Open Systems Pharmacology Model to the Special Population of Pregnant Women
por: Dallmann, André, et al.
Publicado: (2018)

Lensless Three-Dimensional Quantitative Phase Imaging Using Phase Retrieval Algorithm
por: Anand, Vijayakumar, et al.
Publicado: (2020)

A Tutorial on Target-Mediated Drug Disposition (TMDD) Models
por: Dua, P, et al.
Publicado: (2015)

Correction to: A quantitative systems pharmacology (QSP) model for Pneumocystis treatment in mice
por: Liu, Guan-Sheng, et al.
Publicado: (2019)

A quantitative approach to the choice of number of samples for percentile estimation in bootstrap and visual predictive check analyses
por: Jonsson, E. Niclas, et al.
Publicado: (2022)

Understanding effect site pharmacology of uprifosbuvir, a hepatitis C virus nucleoside inhibitor: Case study of a multidisciplinary modeling approach in drug development
por: van den Berg, Paul, et al.
Publicado: (2021)

Quantitative Prediction of Drug–Drug Interactions Involving Inhibitory Metabolites in Drug Development: How Can Physiologically Based Pharmacokinetic Modeling Help?
por: Templeton, IE, et al.
Publicado: (2016)

Using Intervention Mapping to Develop a Digital Self-Management Program for People With Type 2 Diabetes: Tutorial on MyDESMOND
por: Hadjiconstantinou, Michelle, et al.
Publicado: (2020)

Creating the Map of Interactive Services Aiding and Assisting Persons With Disabilities (MSAADA) Project: Tutorial for the Novel Use of a Store Locator App
por: Etling, Mary Ann, et al.
Publicado: (2022)

Application of quantitative systems pharmacology to guide the optimal dosing of COVID‐19 vaccines
por: Giorgi, Mario, et al.
Publicado: (2021)

Development of an Automatic Pill Image Data Generation System
por: Lee, Juhui, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_iik1gbruah1qbdun7lsp8undsr