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Physiologically based pharmacokinetic modeling of levetiracetam to predict the exposure in hepatic and renal impairment and elderly populations

Levetiracetam (LEV) is an anti‐epileptic drug approved for use in various populations. The pharmacokinetic (PK) behavior of LEV may be altered in the elderly and patients with renal and hepatic impairment. Thus, dosage adjustment is required. This study was conducted to investigate how the physiolog...

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Detalles Bibliográficos
Autores principales: Shen, Chaozhuang, Shao, Wenxin, Wang, Wenhui, Sun, Hua, Wang, Xiaohu, Geng, Kuo, Wang, Xingwen, Xie, Haitang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349187/
https://www.ncbi.nlm.nih.gov/pubmed/37170680
http://dx.doi.org/10.1002/psp4.12971