Cargando…
Model‐informed pediatric dose selection of marzeptacog alfa (activated): An exposure matching strategy
Marzeptacog alfa (activated) (MarzAA) is an activated recombinant human rFVII variant intended for subcutaneous (s.c.) administration to treat or prevent bleeding in individuals with hemophilia A (HA) or B (HB) with inhibitors, and other rare bleeding disorders. The s.c. administration provides bene...
Autores principales: | Faraj, Alan, van Wijk, Rob C., Neuman, Linda, Desai, Shraddha, Blouse, Grant E., Knudsen, Tom, Simonsson, Ulrika S. H. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349190/ https://www.ncbi.nlm.nih.gov/pubmed/37042339 http://dx.doi.org/10.1002/psp4.12967 |
Ejemplares similares
-
Phase III dose selection of marzeptacog alfa (activated) informed by population pharmacokinetic modeling: A novel hemostatic drug
por: Faraj, Alan, et al.
Publicado: (2022) -
Model-Informed Support of Dose Selection for Prophylactic Treatment with Dalcinonacog Alfa in Adult and Paediatric Hemophilia B Patients
por: Faraj, Alan, et al.
Publicado: (2023) -
Subcutaneous engineered factor VIIa marzeptacog alfa (activated) in hemophilia with inhibitors: Phase 2 trial of pharmacokinetics, pharmacodynamics, efficacy, and safety
por: Mahlangu, Johnny, et al.
Publicado: (2021) -
Finding the right hazard function for time‐to‐event modeling: A tutorial and Shiny application
por: Van Wijk, Rob C., et al.
Publicado: (2022) -
Standards for model-based early bactericidal activity analysis and sample size determination in tuberculosis drug development
por: Mockeliunas, Laurynas, et al.
Publicado: (2023)