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A population pharmacokinetic and pharmacokinetic‐pharmacodynamic analysis of vupanorsen from phase I and phase II studies

Vupanorsen (PF‐07285557) is a second‐generation ligand‐conjugated 2′O‐methoxyethyl modified antisense oligonucleotide designed to target angiopoietin‐like 3 (ANGPTL3) mRNA expressed by the liver, shown to reduce lipids and apolipoproteins in subjects with dyslipidemia. Using pooled data from two pha...

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Detalles Bibliográficos
Autores principales:	Ahn, Jae Eun, Terra, Steven G., Liu, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349191/ https://www.ncbi.nlm.nih.gov/pubmed/37170423 http://dx.doi.org/10.1002/psp4.12969

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