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Targeted amplicon deep sequencing of ama1 and mdr1 to track within-host P. falciparum diversity throughout treatment in a clinical drug trial

INTRODUCTION: Antimalarial therapeutic efficacy studies are routinely conducted in malaria-endemic countries to assess the effectiveness of antimalarial treatment strategies. Targeted amplicon sequencing (AmpSeq) uniquely identifies and quantifies genetically distinct parasites within an infection....

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Detalles Bibliográficos
Autores principales: Wamae, Kevin, Ndwiga, Leonard, Kharabora, Oksana, Kimenyi, Kelvin, Osoti, Victor, de Laurent, Zaydah, Wambua, Juliana, Musyoki, Jennifer, Ngetsa, Caroline, Kalume, Peter, Mwambingu, Gabriel, Hamaluba, Mainga, van der Pluijm, Rob, Dondorp, Arjen M., Bailey, Jeffrey, Juliano, Jonathan, Bejon, Philip, Ochola-Oyier, Lynette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349275/
https://www.ncbi.nlm.nih.gov/pubmed/37456906
http://dx.doi.org/10.12688/wellcomeopenres.17736.3