Autoantibodies to intrinsic factor can jeopardize pernicious anemia diagnosis: a case report

Vitamin B12 deficiency may cause neurological and hematological alterations. Its assessment should be easy considering that the access to its measurement is available in majority of the clinical laboratories. The presence of technical interference when measuring vitamin B12 can lead to an erroneous...

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Autores principales: Fraile, Lucía, Sopena, Ana, Chávez, Carlos E., Font-Font, Maria, Esquerda, Aureli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Communications and Publications Division (CPD) of the IFCC 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349311/
https://www.ncbi.nlm.nih.gov/pubmed/37455840
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author Fraile, Lucía
Sopena, Ana
Chávez, Carlos E.
Font-Font, Maria
Esquerda, Aureli
author_facet Fraile, Lucía
Sopena, Ana
Chávez, Carlos E.
Font-Font, Maria
Esquerda, Aureli
author_sort Fraile, Lucía
collection PubMed
description Vitamin B12 deficiency may cause neurological and hematological alterations. Its assessment should be easy considering that the access to its measurement is available in majority of the clinical laboratories. The presence of technical interference when measuring vitamin B12 can lead to an erroneous or a more difficult diagnosis of conditions as pernicious anemia. We report a case in which an interference in the evaluation of vitamin B12 concentration led to the realization of invasive tests and almost a misdiagnosis of a patient who actually had pernicious anemia. Professionals need to be aware of these interferences when we assess outcomes.
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spelling pubmed-103493112023-07-16 Autoantibodies to intrinsic factor can jeopardize pernicious anemia diagnosis: a case report Fraile, Lucía Sopena, Ana Chávez, Carlos E. Font-Font, Maria Esquerda, Aureli EJIFCC Case Report Vitamin B12 deficiency may cause neurological and hematological alterations. Its assessment should be easy considering that the access to its measurement is available in majority of the clinical laboratories. The presence of technical interference when measuring vitamin B12 can lead to an erroneous or a more difficult diagnosis of conditions as pernicious anemia. We report a case in which an interference in the evaluation of vitamin B12 concentration led to the realization of invasive tests and almost a misdiagnosis of a patient who actually had pernicious anemia. Professionals need to be aware of these interferences when we assess outcomes. The Communications and Publications Division (CPD) of the IFCC 2023-07-10 /pmc/articles/PMC10349311/ /pubmed/37455840 Text en Copyright © 2023 International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This is a Platinum Open Access Journal distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Fraile, Lucía
Sopena, Ana
Chávez, Carlos E.
Font-Font, Maria
Esquerda, Aureli
Autoantibodies to intrinsic factor can jeopardize pernicious anemia diagnosis: a case report
title Autoantibodies to intrinsic factor can jeopardize pernicious anemia diagnosis: a case report
title_full Autoantibodies to intrinsic factor can jeopardize pernicious anemia diagnosis: a case report
title_fullStr Autoantibodies to intrinsic factor can jeopardize pernicious anemia diagnosis: a case report
title_full_unstemmed Autoantibodies to intrinsic factor can jeopardize pernicious anemia diagnosis: a case report
title_short Autoantibodies to intrinsic factor can jeopardize pernicious anemia diagnosis: a case report
title_sort autoantibodies to intrinsic factor can jeopardize pernicious anemia diagnosis: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349311/
https://www.ncbi.nlm.nih.gov/pubmed/37455840
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