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Ultrasound Triggered Tumor Metabolism Suppressor Induces Tumor Starvation for Enhanced Sonodynamic Immunotherapy of Breast Cancer

INTRODUCTION: Sonodynamic therapy (SDT) as an emerging tumor treatment gained wide attention. However, tumor vascular destruction and oxygen depletion in SDT process may lead to further hypoxia. This may lead to enhanced glycolysis, lactate accumulation, and immunosuppression. METHODS: A glycolysis...

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Autores principales: Qiao, Kun, Luo, Cheng, Huang, Rong, Xiang, Jingfeng, Pan, You, Zhang, Shiyuan, Jiang, Cong, Ding, Shuaijie, Yang, Huawei, Huang, Yuanxi, Ning, Shipeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349352/
https://www.ncbi.nlm.nih.gov/pubmed/37457803
http://dx.doi.org/10.2147/IJN.S413543
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author Qiao, Kun
Luo, Cheng
Huang, Rong
Xiang, Jingfeng
Pan, You
Zhang, Shiyuan
Jiang, Cong
Ding, Shuaijie
Yang, Huawei
Huang, Yuanxi
Ning, Shipeng
author_facet Qiao, Kun
Luo, Cheng
Huang, Rong
Xiang, Jingfeng
Pan, You
Zhang, Shiyuan
Jiang, Cong
Ding, Shuaijie
Yang, Huawei
Huang, Yuanxi
Ning, Shipeng
author_sort Qiao, Kun
collection PubMed
description INTRODUCTION: Sonodynamic therapy (SDT) as an emerging tumor treatment gained wide attention. However, tumor vascular destruction and oxygen depletion in SDT process may lead to further hypoxia. This may lead to enhanced glycolysis, lactate accumulation, and immunosuppression. METHODS: A glycolysis inhibitor (3PO) loaded and PEG modified black phosphorus nanosheets (BO) is constructed for potent starvation therapy and efficient immune activation. RESULTS: Under ultrasound irradiation, the BO can produce ROS to destroy tumors and tumor blood vessels and lead to further hypoxia and nutrients block. Then, the released 3PO inhibits tumor glycolysis and prevents the hypoxia-induced glycolysis and lactate accumulation. Both SDT and 3PO can cut off the source of lactic acid, as well as achieve antitumor starvation therapy through the blockade of the adenosine triphosphate (ATP) supply. In addition, the combination of starvation treatment and SDT further facilitates dendritic cells (DC) maturation, promotes antigen presentation by DCs, and eventually propagates the antitumor immunity and inhibition of abscopal tumor growth. CONCLUSION: This is the first time that combines SDT with inhibition of glycolysis, achieving admirable tumor treatment and decreasing adverse events caused by SDT process and that has caused good immune activation. Our system provides a new idea for the future design of anti-tumor nanomedicines.
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spelling pubmed-103493522023-07-16 Ultrasound Triggered Tumor Metabolism Suppressor Induces Tumor Starvation for Enhanced Sonodynamic Immunotherapy of Breast Cancer Qiao, Kun Luo, Cheng Huang, Rong Xiang, Jingfeng Pan, You Zhang, Shiyuan Jiang, Cong Ding, Shuaijie Yang, Huawei Huang, Yuanxi Ning, Shipeng Int J Nanomedicine Original Research INTRODUCTION: Sonodynamic therapy (SDT) as an emerging tumor treatment gained wide attention. However, tumor vascular destruction and oxygen depletion in SDT process may lead to further hypoxia. This may lead to enhanced glycolysis, lactate accumulation, and immunosuppression. METHODS: A glycolysis inhibitor (3PO) loaded and PEG modified black phosphorus nanosheets (BO) is constructed for potent starvation therapy and efficient immune activation. RESULTS: Under ultrasound irradiation, the BO can produce ROS to destroy tumors and tumor blood vessels and lead to further hypoxia and nutrients block. Then, the released 3PO inhibits tumor glycolysis and prevents the hypoxia-induced glycolysis and lactate accumulation. Both SDT and 3PO can cut off the source of lactic acid, as well as achieve antitumor starvation therapy through the blockade of the adenosine triphosphate (ATP) supply. In addition, the combination of starvation treatment and SDT further facilitates dendritic cells (DC) maturation, promotes antigen presentation by DCs, and eventually propagates the antitumor immunity and inhibition of abscopal tumor growth. CONCLUSION: This is the first time that combines SDT with inhibition of glycolysis, achieving admirable tumor treatment and decreasing adverse events caused by SDT process and that has caused good immune activation. Our system provides a new idea for the future design of anti-tumor nanomedicines. Dove 2023-07-10 /pmc/articles/PMC10349352/ /pubmed/37457803 http://dx.doi.org/10.2147/IJN.S413543 Text en © 2023 Qiao et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Qiao, Kun
Luo, Cheng
Huang, Rong
Xiang, Jingfeng
Pan, You
Zhang, Shiyuan
Jiang, Cong
Ding, Shuaijie
Yang, Huawei
Huang, Yuanxi
Ning, Shipeng
Ultrasound Triggered Tumor Metabolism Suppressor Induces Tumor Starvation for Enhanced Sonodynamic Immunotherapy of Breast Cancer
title Ultrasound Triggered Tumor Metabolism Suppressor Induces Tumor Starvation for Enhanced Sonodynamic Immunotherapy of Breast Cancer
title_full Ultrasound Triggered Tumor Metabolism Suppressor Induces Tumor Starvation for Enhanced Sonodynamic Immunotherapy of Breast Cancer
title_fullStr Ultrasound Triggered Tumor Metabolism Suppressor Induces Tumor Starvation for Enhanced Sonodynamic Immunotherapy of Breast Cancer
title_full_unstemmed Ultrasound Triggered Tumor Metabolism Suppressor Induces Tumor Starvation for Enhanced Sonodynamic Immunotherapy of Breast Cancer
title_short Ultrasound Triggered Tumor Metabolism Suppressor Induces Tumor Starvation for Enhanced Sonodynamic Immunotherapy of Breast Cancer
title_sort ultrasound triggered tumor metabolism suppressor induces tumor starvation for enhanced sonodynamic immunotherapy of breast cancer
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349352/
https://www.ncbi.nlm.nih.gov/pubmed/37457803
http://dx.doi.org/10.2147/IJN.S413543
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