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Association of cardiovascular health at old age with all-cause mortality: a prospective cohort study in China

BACKGROUND: Cardiovascular disease has become the leading cause of death worldwide, but there is a lack of data on whether cardiovascular health (CVH) is associated with elderly mortality in China. We investigated the relationship between the ideal CVH score of Chinese elderly and the all-cause mort...

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Autores principales: Chen, Shimin, Li, Haowei, Wang, Shengshu, Yang, Shanshan, Liu, Shaohua, Song, Yang, Li, Xuehang, Li, Rongrong, Wang, Jianhua, Liu, Miao, He, Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349403/
https://www.ncbi.nlm.nih.gov/pubmed/37454054
http://dx.doi.org/10.1186/s12877-023-04093-9
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author Chen, Shimin
Li, Haowei
Wang, Shengshu
Yang, Shanshan
Liu, Shaohua
Song, Yang
Li, Xuehang
Li, Rongrong
Wang, Jianhua
Liu, Miao
He, Yao
author_facet Chen, Shimin
Li, Haowei
Wang, Shengshu
Yang, Shanshan
Liu, Shaohua
Song, Yang
Li, Xuehang
Li, Rongrong
Wang, Jianhua
Liu, Miao
He, Yao
author_sort Chen, Shimin
collection PubMed
description BACKGROUND: Cardiovascular disease has become the leading cause of death worldwide, but there is a lack of data on whether cardiovascular health (CVH) is associated with elderly mortality in China. We investigated the relationship between the ideal CVH score of Chinese elderly and the all-cause mortality. METHODS: The Beijing Elderly Comprehensive Health Cohort Study included a total of 4,499 participants aged 60 years and above. The CVH metric was calculated at baseline and had a score ranging from 0 to 12. The relationship of CVH metrics with all-cause mortality was investigated using Cox proportional hazard regression analysis. The robustness of results was tested using subgroup and sensitivity analysis. RESULTS: The median CVH score among participants was 8.00 (2.00), with only 8.0% scoring 11–12 points. 667 deaths were observed during an average follow-up time of 8.2 years. Participants with a CVH score of 11–12 had a decreased risk of all-cause mortality when compared to those with a CVH score of 0–4(HR = 0.584, 95% CI: 0.373–0.913). Participants had a 7.5% lower risk of all-cause death with each unit higher CVH score (HR = 0.925, 95%CI: 0.885–0.967) with a linearly decreasing trend (P (nonlinear) = 0.575). The relationships were greater in younger elderly people and stroke patients (P (interaction) = 0.011 and 0.037. respectively). The consistency of significant trends in sensitivity analysis shows the robustness of association (P (trend) < 0.001). CONCLUSIONS: Among the Chinese elderly, there was a linear relationship between improving CVH scores and a lower risk of all-cause mortality. Because of the enormous benefits brought by one point, strategies are essential for improving cardiovascular health attainment. TRIAL REGISTRATION: This study was registered at China Clinical Trial Registration Center (ChiCTR2100049866). SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12877-023-04093-9.
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spelling pubmed-103494032023-07-16 Association of cardiovascular health at old age with all-cause mortality: a prospective cohort study in China Chen, Shimin Li, Haowei Wang, Shengshu Yang, Shanshan Liu, Shaohua Song, Yang Li, Xuehang Li, Rongrong Wang, Jianhua Liu, Miao He, Yao BMC Geriatr Research BACKGROUND: Cardiovascular disease has become the leading cause of death worldwide, but there is a lack of data on whether cardiovascular health (CVH) is associated with elderly mortality in China. We investigated the relationship between the ideal CVH score of Chinese elderly and the all-cause mortality. METHODS: The Beijing Elderly Comprehensive Health Cohort Study included a total of 4,499 participants aged 60 years and above. The CVH metric was calculated at baseline and had a score ranging from 0 to 12. The relationship of CVH metrics with all-cause mortality was investigated using Cox proportional hazard regression analysis. The robustness of results was tested using subgroup and sensitivity analysis. RESULTS: The median CVH score among participants was 8.00 (2.00), with only 8.0% scoring 11–12 points. 667 deaths were observed during an average follow-up time of 8.2 years. Participants with a CVH score of 11–12 had a decreased risk of all-cause mortality when compared to those with a CVH score of 0–4(HR = 0.584, 95% CI: 0.373–0.913). Participants had a 7.5% lower risk of all-cause death with each unit higher CVH score (HR = 0.925, 95%CI: 0.885–0.967) with a linearly decreasing trend (P (nonlinear) = 0.575). The relationships were greater in younger elderly people and stroke patients (P (interaction) = 0.011 and 0.037. respectively). The consistency of significant trends in sensitivity analysis shows the robustness of association (P (trend) < 0.001). CONCLUSIONS: Among the Chinese elderly, there was a linear relationship between improving CVH scores and a lower risk of all-cause mortality. Because of the enormous benefits brought by one point, strategies are essential for improving cardiovascular health attainment. TRIAL REGISTRATION: This study was registered at China Clinical Trial Registration Center (ChiCTR2100049866). SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12877-023-04093-9. BioMed Central 2023-07-15 /pmc/articles/PMC10349403/ /pubmed/37454054 http://dx.doi.org/10.1186/s12877-023-04093-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Chen, Shimin
Li, Haowei
Wang, Shengshu
Yang, Shanshan
Liu, Shaohua
Song, Yang
Li, Xuehang
Li, Rongrong
Wang, Jianhua
Liu, Miao
He, Yao
Association of cardiovascular health at old age with all-cause mortality: a prospective cohort study in China
title Association of cardiovascular health at old age with all-cause mortality: a prospective cohort study in China
title_full Association of cardiovascular health at old age with all-cause mortality: a prospective cohort study in China
title_fullStr Association of cardiovascular health at old age with all-cause mortality: a prospective cohort study in China
title_full_unstemmed Association of cardiovascular health at old age with all-cause mortality: a prospective cohort study in China
title_short Association of cardiovascular health at old age with all-cause mortality: a prospective cohort study in China
title_sort association of cardiovascular health at old age with all-cause mortality: a prospective cohort study in china
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349403/
https://www.ncbi.nlm.nih.gov/pubmed/37454054
http://dx.doi.org/10.1186/s12877-023-04093-9
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