The actions of methotrexate on endothelial cells are dependent on the shear stress-induced regulation of one carbon metabolism

OBJECTIVES: The disease-modifying anti-rheumatic drug methotrexate (MTX) is recognized to reduce cardiovascular risk in patients with systemic inflammatory diseases. However, the molecular basis for these cardioprotective effects remains incompletely understood. This study evaluated the actions of l...

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Detalles Bibliográficos
Autores principales: Lang, Marie B., Leung, Kit-Yi, Greene, Nicholas D.E., Malone, Kerri M., Saginc, Gaye, Randi, Anna M., Kiprianos, Allan, Maughan, Robert T., Pericleous, Charis, Mason, Justin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349526/
https://www.ncbi.nlm.nih.gov/pubmed/37457690
http://dx.doi.org/10.3389/fimmu.2023.1209490

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