Advancing Artificial Intelligence for Clinical Knowledge Retrieval: A Case Study Using ChatGPT-4 and Link Retrieval Plug-In to Analyze Diabetic Ketoacidosis Guidelines

Introduction This case study aimed to enhance the traceability and retrieval accuracy of ChatGPT-4 in medical text by employing a step-by-step systematic approach. The focus was on retrieving clinical answers from three international guidelines on diabetic ketoacidosis (DKA). Methods A systematic methodology was developed to guide the retrieval process. One question was asked per guideline to ensure accuracy and maintain referencing. ChatGPT-4 was utilized to retrieve answers, and the 'Link Reader' plug-in was integrated to facilitate direct access to webpages containing the guidelines. Subsequently, ChatGPT-4 was employed to compile answers while providing citations to the sources. This process was iterated 30 times per question to ensure consistency. In this report, we present our observations regarding the retrieval accuracy, consistency of responses, and the challenges encountered during the process. Results Integrating ChatGPT-4 with the 'Link Reader' plug-in demonstrated notable traceability and retrieval accuracy benefits. The AI model successfully provided relevant and accurate clinical answers based on the analyzed guidelines. Despite occasional challenges with webpage access and minor memory drift, the overall performance of the integrated system was promising. The compilation of the answers was also impressive and held significant promise for further trials. Conclusion The findings of this case study contribute to the utilization of AI text-generation models as valuable tools for medical professionals and researchers. The systematic approach employed in this case study and the integration of the 'Link Reader' plug-in offer a framework for automating medical text synthesis, asking one question at a time before compilation from different sources, which has led to improving AI models' traceability and retrieval accuracy. Further advancements and refinement of AI models and integration with other software utilities hold promise for enhancing the utility and applicability of AI-generated recommendations in medicine and scientific academia. These advancements have the potential to drive significant improvements in everyday medical practice.