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Effect of dexamethasone administration on gonadal-fertility functions in female albino rats
INTRODUCTION: dexamethasone is misused for skin whitening with broad effects on steroidogenesis and ovarian functions. Here in we investigated the impact of dexamethasone administration on gonadotropin Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH), prolactin, and ovarian tissues in...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The African Field Epidemiology Network
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349612/ https://www.ncbi.nlm.nih.gov/pubmed/37455877 http://dx.doi.org/10.11604/pamj.2023.44.160.36748 |
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author | Mohammed, Fatima Yousif Abdrabo, AbdElkarim Abobaker Ahmed, Samia Mahdi Abdulbadie, Ahmed Eltahir, Zakaria Ismail, Amar Mohamed |
author_facet | Mohammed, Fatima Yousif Abdrabo, AbdElkarim Abobaker Ahmed, Samia Mahdi Abdulbadie, Ahmed Eltahir, Zakaria Ismail, Amar Mohamed |
author_sort | Mohammed, Fatima Yousif |
collection | PubMed |
description | INTRODUCTION: dexamethasone is misused for skin whitening with broad effects on steroidogenesis and ovarian functions. Here in we investigated the impact of dexamethasone administration on gonadotropin Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH), prolactin, and ovarian tissues in albino rats. METHODS: in the experimental study, 36 female albino rats weighting (140-162 g) were divided into three groups: control, normal dose received dexamethasone (8.3 μg/kg/day) and high dose (24.9 μg/kg/day), for 30 and 60 days. follicle stimulating hormone, luteinizing hormone, and prolactin (PRL) were measured. Histological ovarian sections were examined. RESULTS: luteinizing hormone, follicle stimulating hormone and prolactin significantly increased (p-value < 0.05) following dexamethasone treatment compared to control. The ovary sections showed degenerative tissue with necrosis of the Graafian follicles, stromal fibrosis, and vacuolation of the interstitial cells. CONCLUSION: the study concludes that dexamethasone administration has a potentially adverse effect on gonadotropin, prolactin, and ovarian follicle cells in female albino rats. |
format | Online Article Text |
id | pubmed-10349612 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The African Field Epidemiology Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-103496122023-07-16 Effect of dexamethasone administration on gonadal-fertility functions in female albino rats Mohammed, Fatima Yousif Abdrabo, AbdElkarim Abobaker Ahmed, Samia Mahdi Abdulbadie, Ahmed Eltahir, Zakaria Ismail, Amar Mohamed Pan Afr Med J Research INTRODUCTION: dexamethasone is misused for skin whitening with broad effects on steroidogenesis and ovarian functions. Here in we investigated the impact of dexamethasone administration on gonadotropin Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH), prolactin, and ovarian tissues in albino rats. METHODS: in the experimental study, 36 female albino rats weighting (140-162 g) were divided into three groups: control, normal dose received dexamethasone (8.3 μg/kg/day) and high dose (24.9 μg/kg/day), for 30 and 60 days. follicle stimulating hormone, luteinizing hormone, and prolactin (PRL) were measured. Histological ovarian sections were examined. RESULTS: luteinizing hormone, follicle stimulating hormone and prolactin significantly increased (p-value < 0.05) following dexamethasone treatment compared to control. The ovary sections showed degenerative tissue with necrosis of the Graafian follicles, stromal fibrosis, and vacuolation of the interstitial cells. CONCLUSION: the study concludes that dexamethasone administration has a potentially adverse effect on gonadotropin, prolactin, and ovarian follicle cells in female albino rats. The African Field Epidemiology Network 2023-04-05 /pmc/articles/PMC10349612/ /pubmed/37455877 http://dx.doi.org/10.11604/pamj.2023.44.160.36748 Text en Copyright: Fatima Yousif Mohammed et al. https://creativecommons.org/licenses/by/4.0/The Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Mohammed, Fatima Yousif Abdrabo, AbdElkarim Abobaker Ahmed, Samia Mahdi Abdulbadie, Ahmed Eltahir, Zakaria Ismail, Amar Mohamed Effect of dexamethasone administration on gonadal-fertility functions in female albino rats |
title | Effect of dexamethasone administration on gonadal-fertility functions in female albino rats |
title_full | Effect of dexamethasone administration on gonadal-fertility functions in female albino rats |
title_fullStr | Effect of dexamethasone administration on gonadal-fertility functions in female albino rats |
title_full_unstemmed | Effect of dexamethasone administration on gonadal-fertility functions in female albino rats |
title_short | Effect of dexamethasone administration on gonadal-fertility functions in female albino rats |
title_sort | effect of dexamethasone administration on gonadal-fertility functions in female albino rats |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349612/ https://www.ncbi.nlm.nih.gov/pubmed/37455877 http://dx.doi.org/10.11604/pamj.2023.44.160.36748 |
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