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Test positivity and clinical presentation of COVID-19 in Mozambican infants hospitalized during the second wave of the pandemic in 2021

INTRODUCTION: during the second wave of the COVID-19 pandemic in Mozambique, there was a surge in pediatric hospitalizations at a time when there was relatively little evidence, but significant concern about clinical outcomes in African children, particularly in higher-risk infants requiring, and he...

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Autores principales: Osório, Dulce, Liasse, Suraia Tane, Cassia, Uneisse, Sidat, Muhammad, Taunde, Sérgio, Mate, Belarmina, Pambo, Elcídio, Mazivila, Otília, Elias, Beatriz, Lorenzoni, Cesaltina, Buck, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The African Field Epidemiology Network 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349623/
https://www.ncbi.nlm.nih.gov/pubmed/37455880
http://dx.doi.org/10.11604/pamj.2023.44.154.38926
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author Osório, Dulce
Liasse, Suraia Tane
Cassia, Uneisse
Sidat, Muhammad
Taunde, Sérgio
Mate, Belarmina
Pambo, Elcídio
Mazivila, Otília
Elias, Beatriz
Lorenzoni, Cesaltina
Buck, Chris
author_facet Osório, Dulce
Liasse, Suraia Tane
Cassia, Uneisse
Sidat, Muhammad
Taunde, Sérgio
Mate, Belarmina
Pambo, Elcídio
Mazivila, Otília
Elias, Beatriz
Lorenzoni, Cesaltina
Buck, Chris
author_sort Osório, Dulce
collection PubMed
description INTRODUCTION: during the second wave of the COVID-19 pandemic in Mozambique, there was a surge in pediatric hospitalizations at a time when there was relatively little evidence, but significant concern about clinical outcomes in African children, particularly in higher-risk infants requiring, and health system capacity to respond. METHODS: a retrospective cohort study was conducted for patients 1-12 months of age admitted to the Breastfeeding ward at Hospital Central de Maputo from January-February 2021. All had routine SARS-CoV-2 PCR testing performed. For patients with positive results, hospital charts were retrospectively reviewed. Descriptive analyses were performed. RESULTS: of 209 patients that had SARS-CoV-2 PCR testing performed, 102 (48.8%) received results, of which 37 (36.3%) were positive. Positive results were received prior to discharge for 14 patients (37.8%). Median duration of hospitalization was 3 days. There were two deaths in COVID-positive patients (5.4%), both with complex comorbidities. For the 35 COVID-19 positive patients whose charts were located, the principal admission diagnosis was respiratory for 22 (62.9%), and 14 (40.0%) had oxygen saturation <94% at admission. The white blood cell count was >12.0 x 10(3)cells/mL in 10 patients (28.6%) and the most common abnormal finding on chest radiograph was peribronchial thickening (38.5% of patients with results). Oxygen therapy was needed for 20 patients (57.1%). CONCLUSION: the majority of infants with COVID-19 had a mild, short-duration respiratory illness that did not exceed ward capacity for care, including oxygen treatment. Laboratory capacity for PCR testing was overwhelmed, delaying the return of results and complicating inpatient infection control measures.
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spelling pubmed-103496232023-07-16 Test positivity and clinical presentation of COVID-19 in Mozambican infants hospitalized during the second wave of the pandemic in 2021 Osório, Dulce Liasse, Suraia Tane Cassia, Uneisse Sidat, Muhammad Taunde, Sérgio Mate, Belarmina Pambo, Elcídio Mazivila, Otília Elias, Beatriz Lorenzoni, Cesaltina Buck, Chris Pan Afr Med J Research INTRODUCTION: during the second wave of the COVID-19 pandemic in Mozambique, there was a surge in pediatric hospitalizations at a time when there was relatively little evidence, but significant concern about clinical outcomes in African children, particularly in higher-risk infants requiring, and health system capacity to respond. METHODS: a retrospective cohort study was conducted for patients 1-12 months of age admitted to the Breastfeeding ward at Hospital Central de Maputo from January-February 2021. All had routine SARS-CoV-2 PCR testing performed. For patients with positive results, hospital charts were retrospectively reviewed. Descriptive analyses were performed. RESULTS: of 209 patients that had SARS-CoV-2 PCR testing performed, 102 (48.8%) received results, of which 37 (36.3%) were positive. Positive results were received prior to discharge for 14 patients (37.8%). Median duration of hospitalization was 3 days. There were two deaths in COVID-positive patients (5.4%), both with complex comorbidities. For the 35 COVID-19 positive patients whose charts were located, the principal admission diagnosis was respiratory for 22 (62.9%), and 14 (40.0%) had oxygen saturation <94% at admission. The white blood cell count was >12.0 x 10(3)cells/mL in 10 patients (28.6%) and the most common abnormal finding on chest radiograph was peribronchial thickening (38.5% of patients with results). Oxygen therapy was needed for 20 patients (57.1%). CONCLUSION: the majority of infants with COVID-19 had a mild, short-duration respiratory illness that did not exceed ward capacity for care, including oxygen treatment. Laboratory capacity for PCR testing was overwhelmed, delaying the return of results and complicating inpatient infection control measures. The African Field Epidemiology Network 2023-03-30 /pmc/articles/PMC10349623/ /pubmed/37455880 http://dx.doi.org/10.11604/pamj.2023.44.154.38926 Text en Copyright: Dulce Osório et al. https://creativecommons.org/licenses/by/4.0/The Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Osório, Dulce
Liasse, Suraia Tane
Cassia, Uneisse
Sidat, Muhammad
Taunde, Sérgio
Mate, Belarmina
Pambo, Elcídio
Mazivila, Otília
Elias, Beatriz
Lorenzoni, Cesaltina
Buck, Chris
Test positivity and clinical presentation of COVID-19 in Mozambican infants hospitalized during the second wave of the pandemic in 2021
title Test positivity and clinical presentation of COVID-19 in Mozambican infants hospitalized during the second wave of the pandemic in 2021
title_full Test positivity and clinical presentation of COVID-19 in Mozambican infants hospitalized during the second wave of the pandemic in 2021
title_fullStr Test positivity and clinical presentation of COVID-19 in Mozambican infants hospitalized during the second wave of the pandemic in 2021
title_full_unstemmed Test positivity and clinical presentation of COVID-19 in Mozambican infants hospitalized during the second wave of the pandemic in 2021
title_short Test positivity and clinical presentation of COVID-19 in Mozambican infants hospitalized during the second wave of the pandemic in 2021
title_sort test positivity and clinical presentation of covid-19 in mozambican infants hospitalized during the second wave of the pandemic in 2021
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349623/
https://www.ncbi.nlm.nih.gov/pubmed/37455880
http://dx.doi.org/10.11604/pamj.2023.44.154.38926
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