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Characteristics and outcome of patients with small bowel adenocarcinoma (SBA)

BACKGROUND: Small bowel adenocarcinoma (SBA) remains a rare malignancy accounting for less than 5% of all the gastrointestinal tract cancers. However, only limited data and expert guidelines are available for this entity. As a result, treatment concepts are predominantly derived from colorectal canc...

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Autores principales: Teufel, Andreas, Meindl-Beinker, Nadja M., Hösel, Pauline, Gerken, Michael, Roig, Ana, Ebert, Matthias P., Herr, Wolfgang, Scheiter, Alexander, Pauer, Armin, Schlitt, Hans J., Klinkhammer-Schalke, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349691/
https://www.ncbi.nlm.nih.gov/pubmed/36163558
http://dx.doi.org/10.1007/s00432-022-04344-z
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author Teufel, Andreas
Meindl-Beinker, Nadja M.
Hösel, Pauline
Gerken, Michael
Roig, Ana
Ebert, Matthias P.
Herr, Wolfgang
Scheiter, Alexander
Pauer, Armin
Schlitt, Hans J.
Klinkhammer-Schalke, Monika
author_facet Teufel, Andreas
Meindl-Beinker, Nadja M.
Hösel, Pauline
Gerken, Michael
Roig, Ana
Ebert, Matthias P.
Herr, Wolfgang
Scheiter, Alexander
Pauer, Armin
Schlitt, Hans J.
Klinkhammer-Schalke, Monika
author_sort Teufel, Andreas
collection PubMed
description BACKGROUND: Small bowel adenocarcinoma (SBA) remains a rare malignancy accounting for less than 5% of all the gastrointestinal tract cancers. However, only limited data and expert guidelines are available for this entity. As a result, treatment concepts are predominantly derived from colorectal cancer. METHODS: To substantiate data on the course of disease, diagnosis and treatment of SBA, we performed a population-based analysis from a Bavarian population of 2.2 million people. RESULTS: We identified 223 patients with SBA. Mean age at diagnosis was 67.8 years and patients were diagnosed rather late (34.5% UICC stage IV). Largest proportion of these patients were diagnosed with adenocarcinoma of the duodenum (132 patients, 59.2%) and most patients were diagnosed with late stage cancer, stage IV (70 patients, 31.4%). With respect to treatment, most patients underwent primary surgery (187 patients, 84.6%). Systemic therapy seemed to have an impact in UICC stage IV patients but not in UICC stage IIB or III. The 5-year survival rate was 29.0%. This was significantly less compared to colon cancer in the same cohort, which was 50.0%. Furthermore, median survival of patients with small bowel cancer was only 2.0 years (95% CI 1.4–2.5) compared to 4.9 years (95% CI 4.8–5.1) of patients with colon cancer. CONCLUSION: SBA showed a distinct epidemiology compared to colon cancer. Thus, data acquisition particularly on systemic treatment are paramount, with the objective to complement the available guidelines. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00432-022-04344-z.
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spelling pubmed-103496912023-07-17 Characteristics and outcome of patients with small bowel adenocarcinoma (SBA) Teufel, Andreas Meindl-Beinker, Nadja M. Hösel, Pauline Gerken, Michael Roig, Ana Ebert, Matthias P. Herr, Wolfgang Scheiter, Alexander Pauer, Armin Schlitt, Hans J. Klinkhammer-Schalke, Monika J Cancer Res Clin Oncol Research BACKGROUND: Small bowel adenocarcinoma (SBA) remains a rare malignancy accounting for less than 5% of all the gastrointestinal tract cancers. However, only limited data and expert guidelines are available for this entity. As a result, treatment concepts are predominantly derived from colorectal cancer. METHODS: To substantiate data on the course of disease, diagnosis and treatment of SBA, we performed a population-based analysis from a Bavarian population of 2.2 million people. RESULTS: We identified 223 patients with SBA. Mean age at diagnosis was 67.8 years and patients were diagnosed rather late (34.5% UICC stage IV). Largest proportion of these patients were diagnosed with adenocarcinoma of the duodenum (132 patients, 59.2%) and most patients were diagnosed with late stage cancer, stage IV (70 patients, 31.4%). With respect to treatment, most patients underwent primary surgery (187 patients, 84.6%). Systemic therapy seemed to have an impact in UICC stage IV patients but not in UICC stage IIB or III. The 5-year survival rate was 29.0%. This was significantly less compared to colon cancer in the same cohort, which was 50.0%. Furthermore, median survival of patients with small bowel cancer was only 2.0 years (95% CI 1.4–2.5) compared to 4.9 years (95% CI 4.8–5.1) of patients with colon cancer. CONCLUSION: SBA showed a distinct epidemiology compared to colon cancer. Thus, data acquisition particularly on systemic treatment are paramount, with the objective to complement the available guidelines. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00432-022-04344-z. Springer Berlin Heidelberg 2022-09-26 2023 /pmc/articles/PMC10349691/ /pubmed/36163558 http://dx.doi.org/10.1007/s00432-022-04344-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Teufel, Andreas
Meindl-Beinker, Nadja M.
Hösel, Pauline
Gerken, Michael
Roig, Ana
Ebert, Matthias P.
Herr, Wolfgang
Scheiter, Alexander
Pauer, Armin
Schlitt, Hans J.
Klinkhammer-Schalke, Monika
Characteristics and outcome of patients with small bowel adenocarcinoma (SBA)
title Characteristics and outcome of patients with small bowel adenocarcinoma (SBA)
title_full Characteristics and outcome of patients with small bowel adenocarcinoma (SBA)
title_fullStr Characteristics and outcome of patients with small bowel adenocarcinoma (SBA)
title_full_unstemmed Characteristics and outcome of patients with small bowel adenocarcinoma (SBA)
title_short Characteristics and outcome of patients with small bowel adenocarcinoma (SBA)
title_sort characteristics and outcome of patients with small bowel adenocarcinoma (sba)
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349691/
https://www.ncbi.nlm.nih.gov/pubmed/36163558
http://dx.doi.org/10.1007/s00432-022-04344-z
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