Nutrient deprivation and hypoxia alter T cell immune checkpoint expression: potential impact for immunotherapy

AIM: Use of immune checkpoint blockade to enhance T cell-mediated immunity within the hostile tumour microenvironment (TME) is an attractive approach in oesophageal adenocarcinoma (OAC). This study explored the effects of the hostile TME, including nutrient deprivation and hypoxia, on immune checkpo...

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Detalles Bibliográficos
Autores principales: Davern, Maria, Donlon, Noel E., O’Connell, Fiona, Gaughan, Caoimhe, O’Donovan, Cillian, McGrath, Jason, Sheppard, Andrew D., Hayes, Conall, King, Ross, Temperley, Hugo, MacLean, Michael, Bulter, Christine, Bhardwaj, Anshul, Moore, Jenny, Donohoe, Claire, Ravi, Narayanasamy, Conroy, Melissa J., Reynolds, John V., Lysaght, Joanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349772/
https://www.ncbi.nlm.nih.gov/pubmed/36445478
http://dx.doi.org/10.1007/s00432-022-04440-0

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