pH-dependence of the Plasmodium falciparum chloroquine resistance transporter is linked to the transport cycle

The chloroquine resistance transporter, PfCRT, of the human malaria parasite Plasmodium falciparum is sensitive to acidic pH. Consequently, PfCRT operates at 60% of its maximal drug transport activity at the pH of 5.2 of the digestive vacuole, a proteolytic organelle from which PfCRT expels drugs in...

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Detalles Bibliográficos
Autores principales: Berger, Fiona, Gomez, Guillermo M., Sanchez, Cecilia P., Posch, Britta, Planelles, Gabrielle, Sohraby, Farzin, Nunes-Alves, Ariane, Lanzer, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349806/
https://www.ncbi.nlm.nih.gov/pubmed/37454114
http://dx.doi.org/10.1038/s41467-023-39969-2

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