β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain

Loss of proteostasis is a hallmark of aging and Alzheimer disease (AD). Here, we identify β-hydroxybutyrate (βHB), a ketone body, as a regulator of protein solubility in the aging brain. βHB is a small molecule metabolite which primarily provides an oxidative substrate for ATP during hypoglycemic co...

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Detalles Bibliográficos
Autores principales: Madhavan, SS, Roa Diaz, S, Peralta, S, Nomura, M, King, CD, Lin, A, Bhaumik, D, Shah, S, Blade, T, Gray, W, Chamoli, M, Eap, B, Panda, O, Diaz, D, Garcia, TY, Stubbs, BJ, Lithgow, GJ, Schilling, B, Verdin, E, Chaudhuri, AR, Newman, JC
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349929/
https://www.ncbi.nlm.nih.gov/pubmed/37461525
http://dx.doi.org/10.1101/2023.07.03.547547

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