Microglia-derived TGF-β1 ligand maintains microglia homeostasis via autocrine mechanism and is critical for normal cognitive function in adult mouse brain

While TGF-β signaling is essential for microglial function, the cellular source of TGF-β ligand and its spatial regulation remains unclear in the adult CNS. Our data support that microglia, not astrocytes or neurons, are the primary producers of TGF-β1 ligands needed for microglial homeostasis. Micr...

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Detalles Bibliográficos
Autores principales: Bedolla, Alicia, Wegman, Elliot, Weed, Max, Paranjpe, Aditi, Alkhimovitch, Anastasia, Ifergan, Igal, McClain, Lucas, Luo, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349967/
https://www.ncbi.nlm.nih.gov/pubmed/37461569
http://dx.doi.org/10.1101/2023.07.05.547814

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