Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome

Hyperactive interferon (IFN) signaling is a hallmark of Down syndrome (DS), a condition caused by trisomy 21 (T21); strategies that normalize IFN signaling could benefit this population. Mediator-associated kinases CDK8 and CDK19 drive inflammatory responses through incompletely understood mechanism...

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Detalles Bibliográficos
Autores principales: Cozzolino, Kira, Sanford, Lynn, Hunter, Samuel, Molison, Kayla, Erickson, Benjamin, Jones, Taylor, Ajit, Deepa, Galbraith, Matthew D., Espinosa, Joaquin M., Bentley, David L., Allen, Mary A., Dowell, Robin D., Taatjes, Dylan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349994/
https://www.ncbi.nlm.nih.gov/pubmed/37461585
http://dx.doi.org/10.1101/2023.07.05.547813

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