APOBEC3 activity promotes the survival and evolution of drug-tolerant persister cells during acquired resistance to EGFR inhibitors in lung cancer

APOBEC mutagenesis is one of the most common endogenous sources of mutations in human cancer and is a major source of genetic intratumor heterogeneity. High levels of APOBEC mutagenesis are associated with poor prognosis and aggressive disease across diverse cancers, but the mechanistic and function...

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Detalles Bibliográficos
Autores principales: Garcia, Nina Marie G., Becerra, Jessica N., McKinney, Brock J., DiMarco, Ashley V., Wu, Feinan, Fitzgibbon, Matthew, Alvarez, James V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350004/
https://www.ncbi.nlm.nih.gov/pubmed/37461590
http://dx.doi.org/10.1101/2023.07.02.547443

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