Molecular Mechanism of a FRET Biosensor for the Cardiac Ryanodine Receptor Pathologically Leaky State

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Ca(2+) leak from cardiomyocyte sarcoplasmic reticulum (SR) via hyperactive resting cardiac ryanodine receptor channels (RyR2) is pro-arrhythmic. An exogenous peptide, (DPc10) detects leaky RyR2 in cardiomyocytes. Conversely, calmodulin (CaM) inhibits RyR2 leak. These observations have led to designi...

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Detalles Bibliográficos
Autores principales: Svensson, Bengt, Nitu, Florentin R., Rebbeck, Robyn T., McGurran, Lindsey M., Oda, Tetsuro, Thomas, David D., Bers, Donald M., Cornea, Razvan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350043/
https://www.ncbi.nlm.nih.gov/pubmed/37461514
http://dx.doi.org/10.1101/2023.07.07.548138
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