Bifunctional small molecules that induce nuclear localization and targeted transcriptional regulation

The aberrant localization of proteins in cells is a key factor in the development of various diseases, including cancer and neurodegenerative disease. To better understand and potentially manipulate protein localization for therapeutic purposes, we engineered bifunctional compounds that bind to prot...

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Detalles Bibliográficos
Autores principales: Gibson, William J., Sadagopan, Ananthan, Shoba, Veronika M., Choudhary, Amit, Meyerson, Matthew, Schreiber, Stuart L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350064/
https://www.ncbi.nlm.nih.gov/pubmed/37461636
http://dx.doi.org/10.1101/2023.07.07.548101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350064/
https://www.ncbi.nlm.nih.gov/pubmed/37461636
http://dx.doi.org/10.1101/2023.07.07.548101

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