A 3’UTR Insertion Is a Candidate Causal Variant at the TMEM106B Locus Associated with Increased Risk for FTLD-TDP

BACKGROUND AND OBJECTIVES: Single nucleotide variants near TMEM106B associate with risk of frontotemporal lobar dementia with TDP-43 inclusions (FTLD-TDP) and Alzheimer’s disease (AD) in genome-wide association studies (GWAS), but the causal variant at this locus remains unclear. Here we asked wheth...

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Detalles Bibliográficos
Autores principales: Chemparathy, Augustine, Guen, Yann Le, Zeng, Yi, Gorzynski, John, Jensen, Tanner, Yang, Chengran, Kasireddy, Nandita, Talozzi, Lia, Belloy, Michael E., Stewart, Ilaria, Gitler, Aaron D., Wagner, Anthony D., Mormino, Elizabeth, Henderson, Victor W., Wyss-Coray, Tony, Ashley, Euan, Cruchaga, Carlos, Greicius, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350161/
https://www.ncbi.nlm.nih.gov/pubmed/37461476
http://dx.doi.org/10.1101/2023.07.06.23292312

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350161/
https://www.ncbi.nlm.nih.gov/pubmed/37461476
http://dx.doi.org/10.1101/2023.07.06.23292312

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