ApoER2-Dab1 disruption as the origin of pTau-related neurodegeneration in sporadic Alzheimer’s disease

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BACKGROUND: Sporadic Alzheimer’s disease (sAD) is not a global brain disease. Specific regions, layers and neurons degenerate early while others remain untouched even in advanced disease. The prevailing model used to explain this selective neurodegeneration—prion-like Tau spread—has key limitations...

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Detalles Bibliográficos
Autores principales: Ramsden, Christopher E, Zamora, Daisy, Horowitz, Mark, Jahanipour, Jahandar, Keyes, Gregory, Li, Xiufeng, Murray, Helen C, Curtis, Maurice A, Faull, Richard M, Sedlock, Andrea, Maric, Dragan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350181/
https://www.ncbi.nlm.nih.gov/pubmed/37461602
http://dx.doi.org/10.21203/rs.3.rs-2968020/v1
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