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Role of GLIS3 in thyroid development and in the regulation of gene expression in thyroid specific Glis3KO mice
Loss of GLI-Similar 3 (GLIS3) function in mice and humans causes congenital hypothyroidism (CH). In this study, we demonstrate that GLIS3 protein is first detectable at E15.5 of murine thyroid development, a time when GLIS3 target genes, such as Slc5a5 (Nis), become also expressed. We further show t...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Journal Experts
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350233/ https://www.ncbi.nlm.nih.gov/pubmed/37461635 http://dx.doi.org/10.21203/rs.3.rs-3044388/v1 |