A new strategy for the determination of the antidiabetics alogliptin, saxagliptin and vildagliptin using all-solid state potentiometric sensors

Herein, we report on the development of disposable screen printed carbon, nanostructure thin film Au/Pt and Pt/Pt all-solid state potentiometric sensors for some antidiabetic compounds called glibtins. The electrodes showed excellent calibration curves (1 × 10(–5)–1 × 10(–2) M) for alogliptin, saxag...

Descripción completa

Detalles Bibliográficos
Autores principales: Derar, Abeer Rashad, Ahmed, Neven, Hussien, Emad Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350275/
https://www.ncbi.nlm.nih.gov/pubmed/37455315
http://dx.doi.org/10.1186/s13065-023-00988-1
_version_ 1785074102353002496
author Derar, Abeer Rashad
Ahmed, Neven
Hussien, Emad Mohamed
author_facet Derar, Abeer Rashad
Ahmed, Neven
Hussien, Emad Mohamed
author_sort Derar, Abeer Rashad
collection PubMed
description Herein, we report on the development of disposable screen printed carbon, nanostructure thin film Au/Pt and Pt/Pt all-solid state potentiometric sensors for some antidiabetic compounds called glibtins. The electrodes showed excellent calibration curves (1 × 10(–5)–1 × 10(–2) M) for alogliptin, saxagliptin and vildagliptin. The electrodes were fully characterized with respect to potential stability, dynamic response time, detection limit, effect of pH and interference according to the IUPAC recommendation. The proposed method is rapid and can be applied for the determination of gliptins at low cost with satisfactory precision (RSD ≤ 1%) and accuracy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13065-023-00988-1.
format Online
Article
Text
id pubmed-10350275
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Springer International Publishing
record_format MEDLINE/PubMed
spelling pubmed-103502752023-07-17 A new strategy for the determination of the antidiabetics alogliptin, saxagliptin and vildagliptin using all-solid state potentiometric sensors Derar, Abeer Rashad Ahmed, Neven Hussien, Emad Mohamed BMC Chem Research Herein, we report on the development of disposable screen printed carbon, nanostructure thin film Au/Pt and Pt/Pt all-solid state potentiometric sensors for some antidiabetic compounds called glibtins. The electrodes showed excellent calibration curves (1 × 10(–5)–1 × 10(–2) M) for alogliptin, saxagliptin and vildagliptin. The electrodes were fully characterized with respect to potential stability, dynamic response time, detection limit, effect of pH and interference according to the IUPAC recommendation. The proposed method is rapid and can be applied for the determination of gliptins at low cost with satisfactory precision (RSD ≤ 1%) and accuracy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13065-023-00988-1. Springer International Publishing 2023-07-16 /pmc/articles/PMC10350275/ /pubmed/37455315 http://dx.doi.org/10.1186/s13065-023-00988-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Derar, Abeer Rashad
Ahmed, Neven
Hussien, Emad Mohamed
A new strategy for the determination of the antidiabetics alogliptin, saxagliptin and vildagliptin using all-solid state potentiometric sensors
title A new strategy for the determination of the antidiabetics alogliptin, saxagliptin and vildagliptin using all-solid state potentiometric sensors
title_full A new strategy for the determination of the antidiabetics alogliptin, saxagliptin and vildagliptin using all-solid state potentiometric sensors
title_fullStr A new strategy for the determination of the antidiabetics alogliptin, saxagliptin and vildagliptin using all-solid state potentiometric sensors
title_full_unstemmed A new strategy for the determination of the antidiabetics alogliptin, saxagliptin and vildagliptin using all-solid state potentiometric sensors
title_short A new strategy for the determination of the antidiabetics alogliptin, saxagliptin and vildagliptin using all-solid state potentiometric sensors
title_sort new strategy for the determination of the antidiabetics alogliptin, saxagliptin and vildagliptin using all-solid state potentiometric sensors
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350275/
https://www.ncbi.nlm.nih.gov/pubmed/37455315
http://dx.doi.org/10.1186/s13065-023-00988-1
work_keys_str_mv AT derarabeerrashad anewstrategyforthedeterminationoftheantidiabeticsalogliptinsaxagliptinandvildagliptinusingallsolidstatepotentiometricsensors
AT ahmedneven anewstrategyforthedeterminationoftheantidiabeticsalogliptinsaxagliptinandvildagliptinusingallsolidstatepotentiometricsensors
AT hussienemadmohamed anewstrategyforthedeterminationoftheantidiabeticsalogliptinsaxagliptinandvildagliptinusingallsolidstatepotentiometricsensors
AT derarabeerrashad newstrategyforthedeterminationoftheantidiabeticsalogliptinsaxagliptinandvildagliptinusingallsolidstatepotentiometricsensors
AT ahmedneven newstrategyforthedeterminationoftheantidiabeticsalogliptinsaxagliptinandvildagliptinusingallsolidstatepotentiometricsensors
AT hussienemadmohamed newstrategyforthedeterminationoftheantidiabeticsalogliptinsaxagliptinandvildagliptinusingallsolidstatepotentiometricsensors

Ejemplares similares