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Hypoparathyroidism and Fahr’s Syndrome: A Case Series

Fahr’s syndrome is defined by the presence of striato-pallido-dentate calcifications. It is a rare entity with clinical polymorphism, and it occurs in patients with dysparathyroidism, especially those with hypoparathyroidism. It must be distinguished from Fahr’s disease (FD), which is defined by the...

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Autores principales: Berrabeh, Soumiya, Messaoudi, Najoua, Elmehraoui, Ouafae, Assarrar, Imane, Karabila, Ikram, Jamal, Anouar, Zeryouh, Nabila, Rouf, Siham, Latrech, Hanane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350282/
https://www.ncbi.nlm.nih.gov/pubmed/37461775
http://dx.doi.org/10.7759/cureus.40502
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author Berrabeh, Soumiya
Messaoudi, Najoua
Elmehraoui, Ouafae
Assarrar, Imane
Karabila, Ikram
Jamal, Anouar
Zeryouh, Nabila
Rouf, Siham
Latrech, Hanane
author_facet Berrabeh, Soumiya
Messaoudi, Najoua
Elmehraoui, Ouafae
Assarrar, Imane
Karabila, Ikram
Jamal, Anouar
Zeryouh, Nabila
Rouf, Siham
Latrech, Hanane
author_sort Berrabeh, Soumiya
collection PubMed
description Fahr’s syndrome is defined by the presence of striato-pallido-dentate calcifications. It is a rare entity with clinical polymorphism, and it occurs in patients with dysparathyroidism, especially those with hypoparathyroidism. It must be distinguished from Fahr’s disease (FD), which is defined by the presence of intracerebral calcifications without phosphocalcic metabolism abnormality. In this paper, we report the particulars of five patients diagnosed with Fahr’s syndrome revealed by neurological and cognitive disorders, seizures, and abnormal movements associated with tetany crisis. In all cases, brain imaging and biological examinations led to the diagnosis of Fahr’s syndrome related to hypoparathyroidism. The evolution was favorable after treatment. Fahr’s syndrome is a rare and serious condition for which treatment is simple and effective. Our observations shed light on the necessity of evaluating phosphocalcic metabolism and exploring cerebral calcifications in patients with neurological disorders.
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spelling pubmed-103502822023-07-17 Hypoparathyroidism and Fahr’s Syndrome: A Case Series Berrabeh, Soumiya Messaoudi, Najoua Elmehraoui, Ouafae Assarrar, Imane Karabila, Ikram Jamal, Anouar Zeryouh, Nabila Rouf, Siham Latrech, Hanane Cureus Endocrinology/Diabetes/Metabolism Fahr’s syndrome is defined by the presence of striato-pallido-dentate calcifications. It is a rare entity with clinical polymorphism, and it occurs in patients with dysparathyroidism, especially those with hypoparathyroidism. It must be distinguished from Fahr’s disease (FD), which is defined by the presence of intracerebral calcifications without phosphocalcic metabolism abnormality. In this paper, we report the particulars of five patients diagnosed with Fahr’s syndrome revealed by neurological and cognitive disorders, seizures, and abnormal movements associated with tetany crisis. In all cases, brain imaging and biological examinations led to the diagnosis of Fahr’s syndrome related to hypoparathyroidism. The evolution was favorable after treatment. Fahr’s syndrome is a rare and serious condition for which treatment is simple and effective. Our observations shed light on the necessity of evaluating phosphocalcic metabolism and exploring cerebral calcifications in patients with neurological disorders. Cureus 2023-06-16 /pmc/articles/PMC10350282/ /pubmed/37461775 http://dx.doi.org/10.7759/cureus.40502 Text en Copyright © 2023, Berrabeh et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Berrabeh, Soumiya
Messaoudi, Najoua
Elmehraoui, Ouafae
Assarrar, Imane
Karabila, Ikram
Jamal, Anouar
Zeryouh, Nabila
Rouf, Siham
Latrech, Hanane
Hypoparathyroidism and Fahr’s Syndrome: A Case Series
title Hypoparathyroidism and Fahr’s Syndrome: A Case Series
title_full Hypoparathyroidism and Fahr’s Syndrome: A Case Series
title_fullStr Hypoparathyroidism and Fahr’s Syndrome: A Case Series
title_full_unstemmed Hypoparathyroidism and Fahr’s Syndrome: A Case Series
title_short Hypoparathyroidism and Fahr’s Syndrome: A Case Series
title_sort hypoparathyroidism and fahr’s syndrome: a case series
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350282/
https://www.ncbi.nlm.nih.gov/pubmed/37461775
http://dx.doi.org/10.7759/cureus.40502
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