Gilteritinib Affects the Selection of Dominant Clones in Clonal Hematopoiesis: Sequential Genetic Analysis of an FLT3-ITD Positive AML Patient with Long-Term Gilteritinib Therapy

We performed sequential molecular analyses of a 75-year-old woman with de novo FLT3-ITD positive acute myeloid leukemia (AML) who had received gilteritinib therapy for 43 months. At the time of diagnosis, her karyotype was normal; however, FLT3-ITD, NPM1, DNMT3A, and IDH2 mutations were detected. Sh...

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Detalles Bibliográficos
Autores principales: Katagiri, Seiichiro, Furuya, Nahoko, Akahane, Daigo, Chi, SungGi, Minami, Yosuke, Harada, Yuka, Harada, Hironori, Gotoh, Akihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350419/
https://www.ncbi.nlm.nih.gov/pubmed/37465589
http://dx.doi.org/10.2147/OTT.S417137

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