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Red-Complex Bacterial Levels in Pregnant Women With Preeclampsia and Chronic Periodontitis

OBJECTIVES: The presence of red-complex bacteria (RCB) has been associated with the occurrence of not only periodontal disease but also other systemic diseases, thereby potentiating an oral–systemic relationship. This study aimed to explore the levels of periodontal RCB in pregnant preeclamptic wome...

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Autores principales: Mahendra, Jaideep, Mahendra, Little, Sharma, Vivek, Alamoudi, Ahmed, Bahammam, Hammam Ahmed, Mugri, Maryam H, Bahammam, Sarah Ahmed, Bahammam, Maha A., Zidane, Bassam, Abirami Nayaki, Rao P., Muralidharan, Janani, Dave, Pavithra H., Balaji, Thodur Madapusi, Bhandi, Shilpa, Patil, Shankargouda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350591/
https://www.ncbi.nlm.nih.gov/pubmed/36411127
http://dx.doi.org/10.1016/j.identj.2022.10.003
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author Mahendra, Jaideep
Mahendra, Little
Sharma, Vivek
Alamoudi, Ahmed
Bahammam, Hammam Ahmed
Mugri, Maryam H
Bahammam, Sarah Ahmed
Bahammam, Maha A.
Zidane, Bassam
Abirami Nayaki, Rao P.
Muralidharan, Janani
Dave, Pavithra H.
Balaji, Thodur Madapusi
Bhandi, Shilpa
Patil, Shankargouda
author_facet Mahendra, Jaideep
Mahendra, Little
Sharma, Vivek
Alamoudi, Ahmed
Bahammam, Hammam Ahmed
Mugri, Maryam H
Bahammam, Sarah Ahmed
Bahammam, Maha A.
Zidane, Bassam
Abirami Nayaki, Rao P.
Muralidharan, Janani
Dave, Pavithra H.
Balaji, Thodur Madapusi
Bhandi, Shilpa
Patil, Shankargouda
author_sort Mahendra, Jaideep
collection PubMed
description OBJECTIVES: The presence of red-complex bacteria (RCB) has been associated with the occurrence of not only periodontal disease but also other systemic diseases, thereby potentiating an oral–systemic relationship. This study aimed to explore the levels of periodontal RCB in pregnant preeclamptic women with periodontal disease, potentiating the pathophysiology of a bacterial association in both periodontitis and preeclampsia. METHODS: Six hundred pregnant women (aged 20 to 35 years) in their third trimester were selected and divided into 3 groups comprising a control group (systemically and periodontally healthy pregnant women), group A (preeclamptic women with chronic periodontitis), and group B (preeclamptic women without chronic periodontitis). Demographic variables and periodontal parameters were recorded. Other variables such as systolic blood pressure (SBP) and diastolic blood pressure (DBP) and the urine protein content were also estimated. RCB, namely Porphyromonas gingivalis (Pg), Treponema denticola (Td), and Tenerella forsythia (Tf), were assessed in both subgingival plaque samples and placental samples of all the pregnant participants in the study. RESULTS: The mean weight, mean body mass index, mean SBP, mean DBP, and mean urine protein content were significantly elevated in group A and group B when compared to the control group. Preeclamptic women with chronic periodontitis (group A) had higher levels of plaque index, probing pocket depth, bleeding on probing, and clinical attachment level as compared with the other groups. The numbers of the RCB were found to be elevated in group A, out of which Pg was found to be more prevalent. CONCLUSIONS: Our findings indicate that the periodontal indices, blood pressure, and urine protein content were found to be higher in preeclamptic women with periodontitis. Hence, reducing the periodontal bacterial load in pregnant women via good oral hygiene maintenance would further reduce the putative risk of adverse pregnancy outcomes including preeclampsia in these women.
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spelling pubmed-103505912023-07-18 Red-Complex Bacterial Levels in Pregnant Women With Preeclampsia and Chronic Periodontitis Mahendra, Jaideep Mahendra, Little Sharma, Vivek Alamoudi, Ahmed Bahammam, Hammam Ahmed Mugri, Maryam H Bahammam, Sarah Ahmed Bahammam, Maha A. Zidane, Bassam Abirami Nayaki, Rao P. Muralidharan, Janani Dave, Pavithra H. Balaji, Thodur Madapusi Bhandi, Shilpa Patil, Shankargouda Int Dent J Scientific Research Report OBJECTIVES: The presence of red-complex bacteria (RCB) has been associated with the occurrence of not only periodontal disease but also other systemic diseases, thereby potentiating an oral–systemic relationship. This study aimed to explore the levels of periodontal RCB in pregnant preeclamptic women with periodontal disease, potentiating the pathophysiology of a bacterial association in both periodontitis and preeclampsia. METHODS: Six hundred pregnant women (aged 20 to 35 years) in their third trimester were selected and divided into 3 groups comprising a control group (systemically and periodontally healthy pregnant women), group A (preeclamptic women with chronic periodontitis), and group B (preeclamptic women without chronic periodontitis). Demographic variables and periodontal parameters were recorded. Other variables such as systolic blood pressure (SBP) and diastolic blood pressure (DBP) and the urine protein content were also estimated. RCB, namely Porphyromonas gingivalis (Pg), Treponema denticola (Td), and Tenerella forsythia (Tf), were assessed in both subgingival plaque samples and placental samples of all the pregnant participants in the study. RESULTS: The mean weight, mean body mass index, mean SBP, mean DBP, and mean urine protein content were significantly elevated in group A and group B when compared to the control group. Preeclamptic women with chronic periodontitis (group A) had higher levels of plaque index, probing pocket depth, bleeding on probing, and clinical attachment level as compared with the other groups. The numbers of the RCB were found to be elevated in group A, out of which Pg was found to be more prevalent. CONCLUSIONS: Our findings indicate that the periodontal indices, blood pressure, and urine protein content were found to be higher in preeclamptic women with periodontitis. Hence, reducing the periodontal bacterial load in pregnant women via good oral hygiene maintenance would further reduce the putative risk of adverse pregnancy outcomes including preeclampsia in these women. Elsevier 2022-11-18 /pmc/articles/PMC10350591/ /pubmed/36411127 http://dx.doi.org/10.1016/j.identj.2022.10.003 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Scientific Research Report
Mahendra, Jaideep
Mahendra, Little
Sharma, Vivek
Alamoudi, Ahmed
Bahammam, Hammam Ahmed
Mugri, Maryam H
Bahammam, Sarah Ahmed
Bahammam, Maha A.
Zidane, Bassam
Abirami Nayaki, Rao P.
Muralidharan, Janani
Dave, Pavithra H.
Balaji, Thodur Madapusi
Bhandi, Shilpa
Patil, Shankargouda
Red-Complex Bacterial Levels in Pregnant Women With Preeclampsia and Chronic Periodontitis
title Red-Complex Bacterial Levels in Pregnant Women With Preeclampsia and Chronic Periodontitis
title_full Red-Complex Bacterial Levels in Pregnant Women With Preeclampsia and Chronic Periodontitis
title_fullStr Red-Complex Bacterial Levels in Pregnant Women With Preeclampsia and Chronic Periodontitis
title_full_unstemmed Red-Complex Bacterial Levels in Pregnant Women With Preeclampsia and Chronic Periodontitis
title_short Red-Complex Bacterial Levels in Pregnant Women With Preeclampsia and Chronic Periodontitis
title_sort red-complex bacterial levels in pregnant women with preeclampsia and chronic periodontitis
topic Scientific Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350591/
https://www.ncbi.nlm.nih.gov/pubmed/36411127
http://dx.doi.org/10.1016/j.identj.2022.10.003
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