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Nanoparticle-based drug delivery systems targeting cancer cell surfaces

Traditional cancer chemotherapy easily produces serious toxic and side effects due to the lack of specific selection of tumor cells, which restricts its curative effect. Targeted delivery can increase the concentration of drugs in the target site and reduce their toxic and side effects on normal tis...

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Detalles Bibliográficos
Autores principales: Hong, Liquan, Li, Wen, Li, Yang, Yin, Shouchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350659/
https://www.ncbi.nlm.nih.gov/pubmed/37465582
http://dx.doi.org/10.1039/d3ra02969g
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author Hong, Liquan
Li, Wen
Li, Yang
Yin, Shouchun
author_facet Hong, Liquan
Li, Wen
Li, Yang
Yin, Shouchun
author_sort Hong, Liquan
collection PubMed
description Traditional cancer chemotherapy easily produces serious toxic and side effects due to the lack of specific selection of tumor cells, which restricts its curative effect. Targeted delivery can increase the concentration of drugs in the target site and reduce their toxic and side effects on normal tissues and cells. Biocompatible and surface-modifiable nanocarriers are novel drug delivery systems, which are used to specifically target tumor sites in a controllable way. One of the effective ways to design effective targeting nanocarriers is to decorate with functional ligands, which can bind to specific receptors overexpressed on the surfaces of cancer cells. Various functional ligands, including transferrin, folic acid, polypeptide and hyaluronic acid, have been widely explored to develop tumor-selective drug delivery systems. This review focuses on the research progress of various receptors overexpressed on the surfaces of cancer cells and different nano-delivery systems of anticancer drugs targeted on the surfaces of cancer cells. We believe that through continuous research and development, actively targeted cancer nano-drugs will make a breakthrough and become an indispensable platform for accurate cancer treatment.
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spelling pubmed-103506592023-07-18 Nanoparticle-based drug delivery systems targeting cancer cell surfaces Hong, Liquan Li, Wen Li, Yang Yin, Shouchun RSC Adv Chemistry Traditional cancer chemotherapy easily produces serious toxic and side effects due to the lack of specific selection of tumor cells, which restricts its curative effect. Targeted delivery can increase the concentration of drugs in the target site and reduce their toxic and side effects on normal tissues and cells. Biocompatible and surface-modifiable nanocarriers are novel drug delivery systems, which are used to specifically target tumor sites in a controllable way. One of the effective ways to design effective targeting nanocarriers is to decorate with functional ligands, which can bind to specific receptors overexpressed on the surfaces of cancer cells. Various functional ligands, including transferrin, folic acid, polypeptide and hyaluronic acid, have been widely explored to develop tumor-selective drug delivery systems. This review focuses on the research progress of various receptors overexpressed on the surfaces of cancer cells and different nano-delivery systems of anticancer drugs targeted on the surfaces of cancer cells. We believe that through continuous research and development, actively targeted cancer nano-drugs will make a breakthrough and become an indispensable platform for accurate cancer treatment. The Royal Society of Chemistry 2023-07-17 /pmc/articles/PMC10350659/ /pubmed/37465582 http://dx.doi.org/10.1039/d3ra02969g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Hong, Liquan
Li, Wen
Li, Yang
Yin, Shouchun
Nanoparticle-based drug delivery systems targeting cancer cell surfaces
title Nanoparticle-based drug delivery systems targeting cancer cell surfaces
title_full Nanoparticle-based drug delivery systems targeting cancer cell surfaces
title_fullStr Nanoparticle-based drug delivery systems targeting cancer cell surfaces
title_full_unstemmed Nanoparticle-based drug delivery systems targeting cancer cell surfaces
title_short Nanoparticle-based drug delivery systems targeting cancer cell surfaces
title_sort nanoparticle-based drug delivery systems targeting cancer cell surfaces
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350659/
https://www.ncbi.nlm.nih.gov/pubmed/37465582
http://dx.doi.org/10.1039/d3ra02969g
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AT liyang nanoparticlebaseddrugdeliverysystemstargetingcancercellsurfaces
AT yinshouchun nanoparticlebaseddrugdeliverysystemstargetingcancercellsurfaces