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Viral recognition and the antiviral interferon response
Interferons (IFNs) are antiviral cytokines that play a key role in the innate immune response to viral infections. In response to viral stimuli, cells produce and release interferons, which then act on neighboring cells to induce the transcription of hundreds of genes. Many of these gene products ei...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350828/ https://www.ncbi.nlm.nih.gov/pubmed/37367474 http://dx.doi.org/10.15252/embj.2022112907 |
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author | Dalskov, Louise Gad, Hans Henrik Hartmann, Rune |
author_facet | Dalskov, Louise Gad, Hans Henrik Hartmann, Rune |
author_sort | Dalskov, Louise |
collection | PubMed |
description | Interferons (IFNs) are antiviral cytokines that play a key role in the innate immune response to viral infections. In response to viral stimuli, cells produce and release interferons, which then act on neighboring cells to induce the transcription of hundreds of genes. Many of these gene products either combat the viral infection directly, e.g., by interfering with viral replication, or help shape the following immune response. Here, we review how viral recognition leads to the production of different types of IFNs and how this production differs in spatial and temporal manners. We then continue to describe how these IFNs play different roles in the ensuing immune response depending on when and where they are produced or act during an infection. |
format | Online Article Text |
id | pubmed-10350828 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103508282023-07-18 Viral recognition and the antiviral interferon response Dalskov, Louise Gad, Hans Henrik Hartmann, Rune EMBO J Review Interferons (IFNs) are antiviral cytokines that play a key role in the innate immune response to viral infections. In response to viral stimuli, cells produce and release interferons, which then act on neighboring cells to induce the transcription of hundreds of genes. Many of these gene products either combat the viral infection directly, e.g., by interfering with viral replication, or help shape the following immune response. Here, we review how viral recognition leads to the production of different types of IFNs and how this production differs in spatial and temporal manners. We then continue to describe how these IFNs play different roles in the ensuing immune response depending on when and where they are produced or act during an infection. John Wiley and Sons Inc. 2023-06-27 /pmc/articles/PMC10350828/ /pubmed/37367474 http://dx.doi.org/10.15252/embj.2022112907 Text en © 2023 Aarhus University. Published under the terms of the CC BY NC ND 4.0 license. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Review Dalskov, Louise Gad, Hans Henrik Hartmann, Rune Viral recognition and the antiviral interferon response |
title | Viral recognition and the antiviral interferon response |
title_full | Viral recognition and the antiviral interferon response |
title_fullStr | Viral recognition and the antiviral interferon response |
title_full_unstemmed | Viral recognition and the antiviral interferon response |
title_short | Viral recognition and the antiviral interferon response |
title_sort | viral recognition and the antiviral interferon response |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350828/ https://www.ncbi.nlm.nih.gov/pubmed/37367474 http://dx.doi.org/10.15252/embj.2022112907 |
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