Reduction of the Renal Radioactivity of (111)In-DOTA-Labeled Antibody Fragments with a Linkage Cleaved by the Renal Brush Border Membrane Enzymes

[Image: see text] The interposition of a cleavable linkage by enzymes on the renal brush border membrane constitutes a promising approach for reducing the renal radioactivity levels of radiolabeled low-molecular-weight antibody fragments and constructs (LMW Abs). Herein, we applied the molecular des...

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Detalles Bibliográficos
Autores principales: Suzuki, Hiroyuki, Araki, Mari, Tatsugi, Kouki, Ichinohe, Kento, Uehara, Tomoya, Arano, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350918/
https://www.ncbi.nlm.nih.gov/pubmed/37322876
http://dx.doi.org/10.1021/acs.jmedchem.3c00258

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