Stapled β-Hairpin Antimicrobial Peptides with Improved Stability and Activity against Drug-Resistant Gram-Negative Bacteria

[Image: see text] Different stapling techniques have been used recently to address the subpar performance of antimicrobial peptides (AMPs) in clinical trials with ample focus on α-helical AMPs. In comparison, a systematic evaluation of such strategies on β-hairpin AMPs is lacking. Herein, we report...

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Detalles Bibliográficos
Autores principales: Selvarajan, Vanitha, Tram, Nhan D. T., Xu, Jian, Ngen, Sarah T. Y., Koh, Jun-Jie, Teo, Jeanette W. P., Yuen, Tsz-Ying, Ee, Pui Lai Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350921/
https://www.ncbi.nlm.nih.gov/pubmed/37357499
http://dx.doi.org/10.1021/acs.jmedchem.3c00140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350921/
https://www.ncbi.nlm.nih.gov/pubmed/37357499
http://dx.doi.org/10.1021/acs.jmedchem.3c00140

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