Design, Synthesis, and Pharmacological Characterization of a Potent Soluble Epoxide Hydrolase Inhibitor for the Treatment of Acute Pancreatitis

[Image: see text] Acute pancreatitis (AP) is a potentially life-threatening illness characterized by an exacerbated inflammatory response with limited options for pharmacological treatment. Here, we describe the rational development of a library of soluble epoxide hydrolase (sEH) inhibitors for the...

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Autores principales: Musella, Simona, D’Avino, Danilo, Peltner, Lukas Klaus, Di Sarno, Veronica, Cerqua, Ida, Merciai, Fabrizio, Vestuto, Vincenzo, Ciaglia, Tania, Smaldone, Gerardina, Di Matteo, Francesca, Di Micco, Simone, Napolitano, Valeria, Bifulco, Giuseppe, Pepe, Giacomo, Sommella, Eduardo Maria, Basilicata, Manuela Giovanna, Aquino, Giovanna, Gomez-Monterrey, Isabel M., Campiglia, Pietro, Ostacolo, Carmine, Roviezzo, Fiorentina, Werz, Oliver, Rossi, Antonietta, Bertamino, Alessia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350924/
https://www.ncbi.nlm.nih.gov/pubmed/37334504
http://dx.doi.org/10.1021/acs.jmedchem.3c00831

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