The Quest for Oral PROTAC drugs: Evaluating the Weaknesses of the Screening Pipeline

[Image: see text] A targeted bibliographic search exposed the deficiencies within existing PROTAC preclinical pipelines, including missing, poor-quality data and technical limitations in the experimental assays. Several recommendations are proposed to improve the efficiency of preclinical platforms...

Descripción completa

Detalles Bibliográficos
Autores principales: Apprato, Giulia, Ermondi, Giuseppe, Caron, Giulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351046/
https://www.ncbi.nlm.nih.gov/pubmed/37465314
http://dx.doi.org/10.1021/acsmedchemlett.3c00231
Descripción
Sumario:[Image: see text] A targeted bibliographic search exposed the deficiencies within existing PROTAC preclinical pipelines, including missing, poor-quality data and technical limitations in the experimental assays. Several recommendations are proposed to improve the efficiency of preclinical platforms for PROTACs.

Ejemplares similares