The Quest for Oral PROTAC drugs: Evaluating the Weaknesses of the Screening Pipeline

[Image: see text] A targeted bibliographic search exposed the deficiencies within existing PROTAC preclinical pipelines, including missing, poor-quality data and technical limitations in the experimental assays. Several recommendations are proposed to improve the efficiency of preclinical platforms...

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Detalles Bibliográficos
Autores principales: Apprato, Giulia, Ermondi, Giuseppe, Caron, Giulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351046/
https://www.ncbi.nlm.nih.gov/pubmed/37465314
http://dx.doi.org/10.1021/acsmedchemlett.3c00231
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author Apprato, Giulia
Ermondi, Giuseppe
Caron, Giulia
author_facet Apprato, Giulia
Ermondi, Giuseppe
Caron, Giulia
author_sort Apprato, Giulia
collection PubMed
description [Image: see text] A targeted bibliographic search exposed the deficiencies within existing PROTAC preclinical pipelines, including missing, poor-quality data and technical limitations in the experimental assays. Several recommendations are proposed to improve the efficiency of preclinical platforms for PROTACs.
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spelling pubmed-103510462023-07-18 The Quest for Oral PROTAC drugs: Evaluating the Weaknesses of the Screening Pipeline Apprato, Giulia Ermondi, Giuseppe Caron, Giulia ACS Med Chem Lett [Image: see text] A targeted bibliographic search exposed the deficiencies within existing PROTAC preclinical pipelines, including missing, poor-quality data and technical limitations in the experimental assays. Several recommendations are proposed to improve the efficiency of preclinical platforms for PROTACs. American Chemical Society 2023-07-03 /pmc/articles/PMC10351046/ /pubmed/37465314 http://dx.doi.org/10.1021/acsmedchemlett.3c00231 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Apprato, Giulia
Ermondi, Giuseppe
Caron, Giulia
The Quest for Oral PROTAC drugs: Evaluating the Weaknesses of the Screening Pipeline
title The Quest for Oral PROTAC drugs: Evaluating the Weaknesses of the Screening Pipeline
title_full The Quest for Oral PROTAC drugs: Evaluating the Weaknesses of the Screening Pipeline
title_fullStr The Quest for Oral PROTAC drugs: Evaluating the Weaknesses of the Screening Pipeline
title_full_unstemmed The Quest for Oral PROTAC drugs: Evaluating the Weaknesses of the Screening Pipeline
title_short The Quest for Oral PROTAC drugs: Evaluating the Weaknesses of the Screening Pipeline
title_sort quest for oral protac drugs: evaluating the weaknesses of the screening pipeline
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351046/
https://www.ncbi.nlm.nih.gov/pubmed/37465314
http://dx.doi.org/10.1021/acsmedchemlett.3c00231
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