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The Quest for Oral PROTAC drugs: Evaluating the Weaknesses of the Screening Pipeline
[Image: see text] A targeted bibliographic search exposed the deficiencies within existing PROTAC preclinical pipelines, including missing, poor-quality data and technical limitations in the experimental assays. Several recommendations are proposed to improve the efficiency of preclinical platforms...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351046/ https://www.ncbi.nlm.nih.gov/pubmed/37465314 http://dx.doi.org/10.1021/acsmedchemlett.3c00231 |