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Fc fragment of IgG binding protein is correlated with immune infiltration levels in hepatocellular carcinoma

The Fc fragment of IgG binding protein (FCGBP) has been confirmed to play an important role in various cancers. However, the specific role of FCGBP in hepatocellular carcinoma (HCC) remains undefined. Thus, in this study, the enrichment analyses (Gene Ontology [GO], Kyoto Encyclopedia of Genes and G...

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Detalles Bibliográficos
Autores principales: Suo, Yuhong, Hou, Chunyu, Yang, Guang, Yuan, Hongfeng, Zhao, Lina, Wang, Yufei, Zhang, Ningning, Zhang, Xiaodong, Lu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351084/
https://www.ncbi.nlm.nih.gov/pubmed/36803544
http://dx.doi.org/10.17305/bb.2022.8586
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author Suo, Yuhong
Hou, Chunyu
Yang, Guang
Yuan, Hongfeng
Zhao, Lina
Wang, Yufei
Zhang, Ningning
Zhang, Xiaodong
Lu, Wei
author_facet Suo, Yuhong
Hou, Chunyu
Yang, Guang
Yuan, Hongfeng
Zhao, Lina
Wang, Yufei
Zhang, Ningning
Zhang, Xiaodong
Lu, Wei
author_sort Suo, Yuhong
collection PubMed
description The Fc fragment of IgG binding protein (FCGBP) has been confirmed to play an important role in various cancers. However, the specific role of FCGBP in hepatocellular carcinoma (HCC) remains undefined. Thus, in this study, the enrichment analyses (Gene Ontology [GO], Kyoto Encyclopedia of Genes and Genomes [KEGG], and Gene Set Enrichment Analysis [GSEA]) of FCGBP in HCC and extensive bioinformatic analyses using data of clinicopathologic characteristics, genetic expression and alterations, and immune cell infiltration were perfomed. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to verify the expression of FCGBP in both HCC tissues and cell lines. The subsequent results confirmed that FCGBP overexpression positively correlated with poor prognosis in patients with HCC. Additionally, FCGBP expression could effectively distinguish tumor tissues from normal tissues, which was verified by qRT-PCR. The result was further confirmed by using HCC cell lines. The time-dependent survival receiver operator characteristic curve exhibited the strong ability of FCGBP to predict survival in patients with HCC. Additionally, we revealed the strong relationship between FCGBP expression and a number of classic regulatory targets and classical oncogenic signaling pathways of tumors. Finally, FCGBP was involved in the regulation of immune infiltration in HCC. Therefore, FCGBP has potential value in the diagnosis, treatment, and prognosis of HCC and may be a potential biomarker or therapeutic target.
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spelling pubmed-103510842023-08-01 Fc fragment of IgG binding protein is correlated with immune infiltration levels in hepatocellular carcinoma Suo, Yuhong Hou, Chunyu Yang, Guang Yuan, Hongfeng Zhao, Lina Wang, Yufei Zhang, Ningning Zhang, Xiaodong Lu, Wei Biomol Biomed Research Article The Fc fragment of IgG binding protein (FCGBP) has been confirmed to play an important role in various cancers. However, the specific role of FCGBP in hepatocellular carcinoma (HCC) remains undefined. Thus, in this study, the enrichment analyses (Gene Ontology [GO], Kyoto Encyclopedia of Genes and Genomes [KEGG], and Gene Set Enrichment Analysis [GSEA]) of FCGBP in HCC and extensive bioinformatic analyses using data of clinicopathologic characteristics, genetic expression and alterations, and immune cell infiltration were perfomed. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to verify the expression of FCGBP in both HCC tissues and cell lines. The subsequent results confirmed that FCGBP overexpression positively correlated with poor prognosis in patients with HCC. Additionally, FCGBP expression could effectively distinguish tumor tissues from normal tissues, which was verified by qRT-PCR. The result was further confirmed by using HCC cell lines. The time-dependent survival receiver operator characteristic curve exhibited the strong ability of FCGBP to predict survival in patients with HCC. Additionally, we revealed the strong relationship between FCGBP expression and a number of classic regulatory targets and classical oncogenic signaling pathways of tumors. Finally, FCGBP was involved in the regulation of immune infiltration in HCC. Therefore, FCGBP has potential value in the diagnosis, treatment, and prognosis of HCC and may be a potential biomarker or therapeutic target. Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2023-08-01 2023-08-01 /pmc/articles/PMC10351084/ /pubmed/36803544 http://dx.doi.org/10.17305/bb.2022.8586 Text en © 2023 Suo et al. https://creativecommons.org/licenses/by/4.0/This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).
spellingShingle Research Article
Suo, Yuhong
Hou, Chunyu
Yang, Guang
Yuan, Hongfeng
Zhao, Lina
Wang, Yufei
Zhang, Ningning
Zhang, Xiaodong
Lu, Wei
Fc fragment of IgG binding protein is correlated with immune infiltration levels in hepatocellular carcinoma
title Fc fragment of IgG binding protein is correlated with immune infiltration levels in hepatocellular carcinoma
title_full Fc fragment of IgG binding protein is correlated with immune infiltration levels in hepatocellular carcinoma
title_fullStr Fc fragment of IgG binding protein is correlated with immune infiltration levels in hepatocellular carcinoma
title_full_unstemmed Fc fragment of IgG binding protein is correlated with immune infiltration levels in hepatocellular carcinoma
title_short Fc fragment of IgG binding protein is correlated with immune infiltration levels in hepatocellular carcinoma
title_sort fc fragment of igg binding protein is correlated with immune infiltration levels in hepatocellular carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351084/
https://www.ncbi.nlm.nih.gov/pubmed/36803544
http://dx.doi.org/10.17305/bb.2022.8586
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