Mapping the neutralizing specificity of human anti-HIV serum by deep mutational scanning

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Understanding the specificities of human serum antibodies that broadly neutralize HIV can inform prevention and treatment strategies. Here, we describe a deep mutational scanning system that can measure the effects of combinations of mutations to HIV envelope (Env) on neutralization by antibodies an...

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Detalles Bibliográficos
Autores principales: Radford, Caelan E., Schommers, Philipp, Gieselmann, Lutz, Crawford, Katharine H.D., Dadonaite, Bernadeta, Yu, Timothy C., Dingens, Adam S., Overbaugh, Julie, Klein, Florian, Bloom, Jesse D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351223/
https://www.ncbi.nlm.nih.gov/pubmed/37327779
http://dx.doi.org/10.1016/j.chom.2023.05.025
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