Potential Utility of Plasma P-Tau and Neurofilament Light Chain as Surrogate Biomarkers for Preventive Clinical Trials

OBJECTIVE: To test the utility of longitudinal changes in plasma phosphorylated tau 181 (p-tau181) and neurofilament light chain (NfL) as surrogate markers for clinical trials targeting cognitively unimpaired (CU) populations. METHODS: We estimated the sample size needed to test a 25% drug effect wi...

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Detalles Bibliográficos
Autores principales: Ferreira, Pamela C.L., Ferrari-Souza, João Pedro, Tissot, Cécile, Bellaver, Bruna, Leffa, Douglas T., Lussier, Firoza, Povala, Guilherme, Therriault, Joseph, Benedet, Andréa L., Ashton, Nicholas J., Cohen, Ann D., Lopez, Oscar L., Tudorascu, Dana L., Klunk, William E., Soucy, Jean-Paul, Gauthier, Serge, Villemagne, Victor, Zetterberg, Henrik, Blennow, Kaj, Rosa-Neto, Pedro, Zimmer, Eduardo R., Karikari, Thomas K., Pascoal, Tharick A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Clinical/Scientific Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351303/
https://www.ncbi.nlm.nih.gov/pubmed/36878697
http://dx.doi.org/10.1212/WNL.0000000000207115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351303/
https://www.ncbi.nlm.nih.gov/pubmed/36878697
http://dx.doi.org/10.1212/WNL.0000000000207115

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