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Predictive Factors for Renal Response in Lupus Nephritis: A Single-center Prospective Cohort Study

OBJECTIVE: To identify the predictive factors for renal response in patients with lupus nephritis (LN). METHODS: Patients and data were extracted from a prospective systemic lupus erythematosus cohort in Korea, in which clinical data were collected at 0, 3, 6, and 12 months after induction therapy....

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Autores principales: Park, Dae Jin, Joo, Young Bin, Bang, So-Young, Lee, Jiyoung, Lee, Hye-Soon, Bae, Sang-Cheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean College of Rheumatology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351413/
https://www.ncbi.nlm.nih.gov/pubmed/37476428
http://dx.doi.org/10.4078/jrd.22.0006
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author Park, Dae Jin
Joo, Young Bin
Bang, So-Young
Lee, Jiyoung
Lee, Hye-Soon
Bae, Sang-Cheol
author_facet Park, Dae Jin
Joo, Young Bin
Bang, So-Young
Lee, Jiyoung
Lee, Hye-Soon
Bae, Sang-Cheol
author_sort Park, Dae Jin
collection PubMed
description OBJECTIVE: To identify the predictive factors for renal response in patients with lupus nephritis (LN). METHODS: Patients and data were extracted from a prospective systemic lupus erythematosus cohort in Korea, in which clinical data were collected at 0, 3, 6, and 12 months after induction therapy. Treatment response of LN were evaluated as a complete response (CR), partial response (PR), or non-response (NR) at 3, 6, and 12 months, respectively. Predictive factors for CR at 6 months were evaluated using multivariable Poisson regression analysis. RESULTS: A total of 75 patients with LN who underwent biopsy was enrolled. The mean age at diagnosis of LN was 28.9±9.7 years, and 68 (90.7%) were female. The frequencies of classes III, IV, III+V, IV+V, and V were 20.0%, 44.0%, 16.0%, 12.0%, and 8.0%, respectively. Compared to relapsed LN, new-onset LN showed a lower percentage of glomerulosclerosis (45.5% vs. 76.2%, p=0.013). The overall proportions of CR, PR, and NR at 6 and 12 months were 52.0%, 26.7%, 21.3% and 50.7%, 24.0%, 25.3%, respectively. In multivariate analysis, age at enrollment (odds ratio [OR]=1.02, p=0.022), relapsed LN (OR=0.71, p=0.037), anti-Ro antibody (OR=0.67, p=0.014), and class III LN (OR=1.48, p=0.001) were associated with CR at 6 months. CONCLUSION: In our prospective cohort, class III LN was a good predictive factor for CR at 6 months in patients with LN, whereas younger age, relapsed LN, and anti-Ro antibody were poor predictive factors.
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spelling pubmed-103514132023-07-20 Predictive Factors for Renal Response in Lupus Nephritis: A Single-center Prospective Cohort Study Park, Dae Jin Joo, Young Bin Bang, So-Young Lee, Jiyoung Lee, Hye-Soon Bae, Sang-Cheol J Rheum Dis Original Article OBJECTIVE: To identify the predictive factors for renal response in patients with lupus nephritis (LN). METHODS: Patients and data were extracted from a prospective systemic lupus erythematosus cohort in Korea, in which clinical data were collected at 0, 3, 6, and 12 months after induction therapy. Treatment response of LN were evaluated as a complete response (CR), partial response (PR), or non-response (NR) at 3, 6, and 12 months, respectively. Predictive factors for CR at 6 months were evaluated using multivariable Poisson regression analysis. RESULTS: A total of 75 patients with LN who underwent biopsy was enrolled. The mean age at diagnosis of LN was 28.9±9.7 years, and 68 (90.7%) were female. The frequencies of classes III, IV, III+V, IV+V, and V were 20.0%, 44.0%, 16.0%, 12.0%, and 8.0%, respectively. Compared to relapsed LN, new-onset LN showed a lower percentage of glomerulosclerosis (45.5% vs. 76.2%, p=0.013). The overall proportions of CR, PR, and NR at 6 and 12 months were 52.0%, 26.7%, 21.3% and 50.7%, 24.0%, 25.3%, respectively. In multivariate analysis, age at enrollment (odds ratio [OR]=1.02, p=0.022), relapsed LN (OR=0.71, p=0.037), anti-Ro antibody (OR=0.67, p=0.014), and class III LN (OR=1.48, p=0.001) were associated with CR at 6 months. CONCLUSION: In our prospective cohort, class III LN was a good predictive factor for CR at 6 months in patients with LN, whereas younger age, relapsed LN, and anti-Ro antibody were poor predictive factors. Korean College of Rheumatology 2022-10-01 2022-07-05 /pmc/articles/PMC10351413/ /pubmed/37476428 http://dx.doi.org/10.4078/jrd.22.0006 Text en Copyright © 2022 by The Korean College of Rheumatology. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Park, Dae Jin
Joo, Young Bin
Bang, So-Young
Lee, Jiyoung
Lee, Hye-Soon
Bae, Sang-Cheol
Predictive Factors for Renal Response in Lupus Nephritis: A Single-center Prospective Cohort Study
title Predictive Factors for Renal Response in Lupus Nephritis: A Single-center Prospective Cohort Study
title_full Predictive Factors for Renal Response in Lupus Nephritis: A Single-center Prospective Cohort Study
title_fullStr Predictive Factors for Renal Response in Lupus Nephritis: A Single-center Prospective Cohort Study
title_full_unstemmed Predictive Factors for Renal Response in Lupus Nephritis: A Single-center Prospective Cohort Study
title_short Predictive Factors for Renal Response in Lupus Nephritis: A Single-center Prospective Cohort Study
title_sort predictive factors for renal response in lupus nephritis: a single-center prospective cohort study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351413/
https://www.ncbi.nlm.nih.gov/pubmed/37476428
http://dx.doi.org/10.4078/jrd.22.0006
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