Application of the Mannich reaction in the structural modification of natural products

The Mannich reaction is commonly used to introduce N atoms into compound molecules and is thus widely applied in drug synthesis. The Mannich reaction accounts for a certain proportion of structural modifications of natural products. The introduction of Mannich bases can significantly improve the act...

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Detalles Bibliográficos
Autores principales: Pu, Miao-Xia, Guo, Hong-Yan, Quan, Zhe-Shan, Li, Xiaoting, Shen, Qing-Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351470/
https://www.ncbi.nlm.nih.gov/pubmed/37449337
http://dx.doi.org/10.1080/14756366.2023.2235095
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author Pu, Miao-Xia
Guo, Hong-Yan
Quan, Zhe-Shan
Li, Xiaoting
Shen, Qing-Kun
author_facet Pu, Miao-Xia
Guo, Hong-Yan
Quan, Zhe-Shan
Li, Xiaoting
Shen, Qing-Kun
author_sort Pu, Miao-Xia
collection PubMed
description The Mannich reaction is commonly used to introduce N atoms into compound molecules and is thus widely applied in drug synthesis. The Mannich reaction accounts for a certain proportion of structural modifications of natural products. The introduction of Mannich bases can significantly improve the activity, hydrophilicity, and medicinal properties of compounds; therefore, the Mannich reaction is widely used for the structural modification of natural products. In this paper, the application of the Mannich reaction to the structural modification of natural products is reviewed, providing a method for the structural modification of natural products.
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spelling pubmed-103514702023-07-18 Application of the Mannich reaction in the structural modification of natural products Pu, Miao-Xia Guo, Hong-Yan Quan, Zhe-Shan Li, Xiaoting Shen, Qing-Kun J Enzyme Inhib Med Chem Review Article The Mannich reaction is commonly used to introduce N atoms into compound molecules and is thus widely applied in drug synthesis. The Mannich reaction accounts for a certain proportion of structural modifications of natural products. The introduction of Mannich bases can significantly improve the activity, hydrophilicity, and medicinal properties of compounds; therefore, the Mannich reaction is widely used for the structural modification of natural products. In this paper, the application of the Mannich reaction to the structural modification of natural products is reviewed, providing a method for the structural modification of natural products. Taylor & Francis 2023-07-14 /pmc/articles/PMC10351470/ /pubmed/37449337 http://dx.doi.org/10.1080/14756366.2023.2235095 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Review Article
Pu, Miao-Xia
Guo, Hong-Yan
Quan, Zhe-Shan
Li, Xiaoting
Shen, Qing-Kun
Application of the Mannich reaction in the structural modification of natural products
title Application of the Mannich reaction in the structural modification of natural products
title_full Application of the Mannich reaction in the structural modification of natural products
title_fullStr Application of the Mannich reaction in the structural modification of natural products
title_full_unstemmed Application of the Mannich reaction in the structural modification of natural products
title_short Application of the Mannich reaction in the structural modification of natural products
title_sort application of the mannich reaction in the structural modification of natural products
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351470/
https://www.ncbi.nlm.nih.gov/pubmed/37449337
http://dx.doi.org/10.1080/14756366.2023.2235095
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