HSPB8 frameshift mutant aggregates weaken chaperone-assisted selective autophagy in neuromyopathies

Chaperone-assisted selective autophagy (CASA) is a highly selective pathway for the disposal of misfolding and aggregating proteins. In muscle, CASA assures muscle integrity by favoring the turnover of structural components damaged by mechanical strain. In neurons, CASA promotes the removal of aggre...

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Detalles Bibliográficos
Autores principales: Tedesco, Barbara, Vendredy, Leen, Adriaenssens, Elias, Cozzi, Marta, Asselbergh, Bob, Crippa, Valeria, Cristofani, Riccardo, Rusmini, Paola, Ferrari, Veronica, Casarotto, Elena, Chierichetti, Marta, Mina, Francesco, Pramaggiore, Paola, Galbiati, Mariarita, Piccolella, Margherita, Baets, Jonathan, Baeke, Femke, De Rycke, Riet, Mouly, Vincent, Laurenzi, Tommaso, Eberini, Ivano, Vihola, Anna, Udd, Bjarne, Weiss, Lan, Kimonis, Virginia, Timmerman, Vincent, Poletti, Angelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351472/
https://www.ncbi.nlm.nih.gov/pubmed/36854646
http://dx.doi.org/10.1080/15548627.2023.2179780

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