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Spectrum of and Factors Associated with Eye Disorders among Rheumatoid Arthritis Patients Attending Tertiary Hospital in Uganda

BACKGROUND: Ocular morbidities associated with rheumatoid arthritis (RA) have not received much attention in Africa, particularly in sub-Saharan Africa. They are among the commonest (40%) extra-articular organ involvement in RA. If undiagnosed, there is a potential risk of them causing visual impair...

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Autores principales: Headcraph, Eunice, Atukunda, Immaculate, Kaddumukasa, Mark, Nakiyingi, Lydia, Lusobya, Rebecca Claire, Ampaire-Musika, Anne, Otike, Caroline, Nagawa, Elizabeth, Juma, Paul, Msonge, Fransisco, Otiti-Sengeri, Juliet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351586/
https://www.ncbi.nlm.nih.gov/pubmed/37465162
http://dx.doi.org/10.2147/OARRR.S413697
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author Headcraph, Eunice
Atukunda, Immaculate
Kaddumukasa, Mark
Nakiyingi, Lydia
Lusobya, Rebecca Claire
Ampaire-Musika, Anne
Otike, Caroline
Nagawa, Elizabeth
Juma, Paul
Msonge, Fransisco
Otiti-Sengeri, Juliet
author_facet Headcraph, Eunice
Atukunda, Immaculate
Kaddumukasa, Mark
Nakiyingi, Lydia
Lusobya, Rebecca Claire
Ampaire-Musika, Anne
Otike, Caroline
Nagawa, Elizabeth
Juma, Paul
Msonge, Fransisco
Otiti-Sengeri, Juliet
author_sort Headcraph, Eunice
collection PubMed
description BACKGROUND: Ocular morbidities associated with rheumatoid arthritis (RA) have not received much attention in Africa, particularly in sub-Saharan Africa. They are among the commonest (40%) extra-articular organ involvement in RA. If undiagnosed, there is a potential risk of them causing visual impairment or blindness. There is no documented study in Uganda on the magnitude of eye disorders among RA patients. AIM: To determine the spectrum of eye disorders and associated factors among patients with RA attending Mulago National Referral Hospital. METHODS: A hospital based cross-sectional study was conducted among adults with RA attending the rheumatology clinic between July 2021 and September 2021. Clinical and sociodemographic data were collected, and ophthalmologic examinations were performed on all consenting participants. Modified Poisson regression with robust standard error was used to determine factors associated with eye disorders. RESULTS: Overall, 105 patients with RA were enrolled, of which, 53 (50.5%) had eye disorders. The commonest disorder (54.7%, n=29) was dry-eye syndrome. Factors that were significantly associated with eye disorders were age 36–55 years (aPR 1.56, p=0.015), duration of RA >5 years (aPR 1.81, p=0.001), use of hydroxychloroquine >5 years (aPR 1.77, p=0.041), dose of oral steroids >10 mg/day (aPR 1.49, p=0.034), and history of both diabetes and hypertension (aPR 1.87, p=0.014). CONCLUSION: The prevalence of eye disorders among patients with RA was high, with the commonest being dry-eye syndrome. We recommend that ocular examinations be performed on every patient at the time of RA diagnosis for early detection of eye disorders.
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spelling pubmed-103515862023-07-18 Spectrum of and Factors Associated with Eye Disorders among Rheumatoid Arthritis Patients Attending Tertiary Hospital in Uganda Headcraph, Eunice Atukunda, Immaculate Kaddumukasa, Mark Nakiyingi, Lydia Lusobya, Rebecca Claire Ampaire-Musika, Anne Otike, Caroline Nagawa, Elizabeth Juma, Paul Msonge, Fransisco Otiti-Sengeri, Juliet Open Access Rheumatol Original Research BACKGROUND: Ocular morbidities associated with rheumatoid arthritis (RA) have not received much attention in Africa, particularly in sub-Saharan Africa. They are among the commonest (40%) extra-articular organ involvement in RA. If undiagnosed, there is a potential risk of them causing visual impairment or blindness. There is no documented study in Uganda on the magnitude of eye disorders among RA patients. AIM: To determine the spectrum of eye disorders and associated factors among patients with RA attending Mulago National Referral Hospital. METHODS: A hospital based cross-sectional study was conducted among adults with RA attending the rheumatology clinic between July 2021 and September 2021. Clinical and sociodemographic data were collected, and ophthalmologic examinations were performed on all consenting participants. Modified Poisson regression with robust standard error was used to determine factors associated with eye disorders. RESULTS: Overall, 105 patients with RA were enrolled, of which, 53 (50.5%) had eye disorders. The commonest disorder (54.7%, n=29) was dry-eye syndrome. Factors that were significantly associated with eye disorders were age 36–55 years (aPR 1.56, p=0.015), duration of RA >5 years (aPR 1.81, p=0.001), use of hydroxychloroquine >5 years (aPR 1.77, p=0.041), dose of oral steroids >10 mg/day (aPR 1.49, p=0.034), and history of both diabetes and hypertension (aPR 1.87, p=0.014). CONCLUSION: The prevalence of eye disorders among patients with RA was high, with the commonest being dry-eye syndrome. We recommend that ocular examinations be performed on every patient at the time of RA diagnosis for early detection of eye disorders. Dove 2023-07-13 /pmc/articles/PMC10351586/ /pubmed/37465162 http://dx.doi.org/10.2147/OARRR.S413697 Text en © 2023 Headcraph et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Headcraph, Eunice
Atukunda, Immaculate
Kaddumukasa, Mark
Nakiyingi, Lydia
Lusobya, Rebecca Claire
Ampaire-Musika, Anne
Otike, Caroline
Nagawa, Elizabeth
Juma, Paul
Msonge, Fransisco
Otiti-Sengeri, Juliet
Spectrum of and Factors Associated with Eye Disorders among Rheumatoid Arthritis Patients Attending Tertiary Hospital in Uganda
title Spectrum of and Factors Associated with Eye Disorders among Rheumatoid Arthritis Patients Attending Tertiary Hospital in Uganda
title_full Spectrum of and Factors Associated with Eye Disorders among Rheumatoid Arthritis Patients Attending Tertiary Hospital in Uganda
title_fullStr Spectrum of and Factors Associated with Eye Disorders among Rheumatoid Arthritis Patients Attending Tertiary Hospital in Uganda
title_full_unstemmed Spectrum of and Factors Associated with Eye Disorders among Rheumatoid Arthritis Patients Attending Tertiary Hospital in Uganda
title_short Spectrum of and Factors Associated with Eye Disorders among Rheumatoid Arthritis Patients Attending Tertiary Hospital in Uganda
title_sort spectrum of and factors associated with eye disorders among rheumatoid arthritis patients attending tertiary hospital in uganda
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351586/
https://www.ncbi.nlm.nih.gov/pubmed/37465162
http://dx.doi.org/10.2147/OARRR.S413697
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