Pulvinar neuromodulation for seizure monitoring and network modulation in temporal plus epilepsy

Deep brain stimulation (DBS) is a promising treatment for drug‐refractory epilepsies (DRE) when targeting the anterior nuclei of thalamus (ANT). However, targeting other thalamic nuclei, such as the pulvinar, shows therapeutic promise. Our pioneering case study presents the application of ambulatory...

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Detalles Bibliográficos
Autores principales: Vakilna, Yash Shashank, Chaitanya, Ganne, Hafeez, Muhammad Ubaid, Ilyas, Adeel, Saranathan, Manojkumar, Gavvala, Jay, Tandon, Nitin, Pati, Sandipan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Case Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351657/
https://www.ncbi.nlm.nih.gov/pubmed/37231611
http://dx.doi.org/10.1002/acn3.51815
Descripción
Sumario:Deep brain stimulation (DBS) is a promising treatment for drug‐refractory epilepsies (DRE) when targeting the anterior nuclei of thalamus (ANT). However, targeting other thalamic nuclei, such as the pulvinar, shows therapeutic promise. Our pioneering case study presents the application of ambulatory seizure monitoring using spectral fingerprinting (12.15–17.15 Hz) recorded through Medtronic Percept DBS implanted bilaterally in the medial pulvinar thalami. This technology offers unprecedented opportunities for real‐time monitoring of seizure burden and thalamocortical network modulation for effective seizure reduction in patients with bilateral mesial temporal and temporal plus epilepsies that are not suitable for resection.

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